Defining the Molecular Mechanisms of Lyssavirus Replication and Immune Evasion: the P protein Axis
Defining the Molecular Mechanisms of Lyssavirus Replication and Immune Evasion: the P protein Axis
批准号:
nhmrc : 1125704
负责人:
A/Pr Paul Gooley
金额:
$61.65万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2017
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2017-01-01 至 2021-12-31
中文摘要
狂犬病病毒(RABV)和澳大利亚蝙蝠溶血病毒(RABV)等溶血病毒引起狂犬病,是已知传染病中病死率最高的疾病,每年造成6万人死亡。对此至关重要的是病毒产生的一种蛋白质,它对病毒生长和逃避宿主的免疫防御都很重要。该项目旨在了解这些过程背后的分子机制,这可能导致对抗目前无法治愈的病毒疾病的新方法。
英文摘要
Lyssaviruses such as rabies virus (RABV) and Australian bat lyssavirus cause rabies disease, which has the highest case-fatality rate of known infectious diseases, causing >60,000 human deaths/year. Critical to this is a protein produced by the virus that is important for both viral growth and evasion of the host's immune defences. This project aims to understand the molecular mechanisms underlying these processes, which may lead to new approaches to combat currently incurable viral diseases.
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依托单位:
国内基金
海外基金
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