DERMAL ABSORPTION OF DIETHANOLAMINE AND TRIETHANOLAMINE IN RATS AND MICE

二乙醇胺(DEA)和三乙醇胺(TEA)被广泛用于 化妆品，如面霜、清洁剂和洗发水。在14个月里- 由国家毒理学计划TEA进行的一天重复剂量研究 发现对大鼠皮肤的毒性比对小鼠皮肤的毒性大 申请。茶叶在F344大鼠和B6C3F1大鼠的皮肤吸收研究 小鼠被用来帮助解释不同物种对 这种化学物质。雄性大鼠和小鼠的肩胛骨被夹住， 并在化学物质的预定位置安装了筛选环 申请。将溶于丙酮的14C-TEA应用于组织内 向大鼠和小鼠致敬。在超过8个时间点采集了血样 给药后48小时，氧化为二氧化碳，并通过 液体闪烁计数。尿液、粪便、组织帽中的放射性 并对涂抹部位的皮肤切片进行计数。茶是 大鼠和小鼠经皮给药后吸收；然而， 小鼠的吸收更大，化学物质的水平保持在 在大鼠中，应用部位更大。相似可比性真皮 DEA在大鼠和小鼠体内的吸收研究正在计划中。

Diethanolamine (DEA) and triethanolamine (TEA) are widely used in cosmetic products such as creams, skin cleaners, and shampoos. In a 14- day repeated-dose study conducted by the National Toxicology Program, TEA was found to be more toxic to the skin of rats than mice after dermal application. Dermal absorption studies of TEA in f344 rats and B6C3F1 mice were initiated to help explain species differences in sensitivity to this chemical. The interscapular are of male rats and mice were clipped, and screened rings were mounted over the intended site of chemical application. 14C-TEA dissolved in acetone was applied within the tissue caps to rats and mice. Blood samples were taken at eight time points over a 48 hour period after dosing, oxidized to CO2 and assayed for 14C by liquid scintillation counting. Radioactivity in urine, feces, tissue caps and skin sections from the site of application were also counted. Tea was absorbed after dermal application in rats and mice; however, the rate of absorption was greater in mice and the level of chemical retained at the site of application was greater in rats. Similar comparative dermal absorption studies of DEA in rats and mice are planned.