FLUORESCENCE-GUIDED LASER ANGIOPLASTY IN PERIPHERAL VASCULAR DISEASE

利用荧光光谱作为指导的新的双激光系统 脉冲染料激光组织消融的模式已经在70个研究 股腘动脉闭塞患者，作为合作的一部分， 多中心评价这个装置，最初的设想和开发， 美国国立卫生研究院和工业界联合研究的一个产品现在正在10个中心使用， 美国和法国。该系统在激光血管成形术中是独一无二的 提供治疗激光的实时引导 利用荧光光谱鉴定所提出的靶位点 这将极大地提高再通效率并减少 透壁穿孔的频率。本研究中接受治疗的患者 有不同长度的股腘动脉闭塞， 使用标准球囊血管成形术成功治疗。在这 患者队列，使用单光纤激光器械进行初次再通 在81%的患者中成功，随后球囊成功 74%的患者行血管成形术。他们没有重大并发症， 荧光光谱有助于识别血栓，在某些情况下， 终止于大分支侧支的冲洗主通道闭塞 血管，并在接近偏心纤维位置的情况下， 潜在介质威胁血管壁穿孔。我们认为这 具有实时引导能力的先进激光血管成形术系统将 是治疗冠状动脉和外周血管疾病的重要工具 疾病

A new dual laser system utilizing fluorescence spectroscopy as a guidance modality for pulsed dye laser tissue ablation has been studied in 70 patients with femoropopliteal occlusions as part of a cooperative multi-center evaluation. This device, originally conceived and developed as a product of joint NIH-industry research is now being used in 10 centers in the United States and France. The system is unique among laser angioplasty devices in that real-time guidance of the treatment laser is provided utilizing florescence spectroscopic identification of proposed target sites which should greatly improve recanalization efficacy and reduce the frequency of transmural perforations. The patients treated in this study had femoropopliteal occlusions of varying lengths which could not be treated successfully using standard balloon angioplasty techniques. In this patient cohort, primary recanalization using the single fiber laser device was successful in 81% of patients followed by successful balloon angioplasty in 74% of patients. Their were no major complications and florescence spectroscopy was helpful in identifying thrombus, in situations of flush main channel occlusions terminating in a large branch collateral vessel, and under circumstances when eccentric fiber position approached underlying media threatening vessel wall perforation. We believe that this advanced laser angioplasty system with real-time guidance capabilities will be an important tool in the treatment of coronary and peripheral vascular disease.