A dendritic cell subset targeting approach for defining immune function and tailoring immunotherapy

树突状细胞是免疫系统的重要前哨细胞，其协调我们对入侵病原体的免疫应答。树突状细胞有不同的类型，它们执行不同的工作。我们有一系列抗体可以识别不同树突细胞群体表面的标记。我们可以使用这些抗体作为归巢装置，将外来物质传递到单个树突状细胞亚群，从而操纵产生的免疫反应类型。有效地，我们的目标是定制免疫反应，以对抗特定的细菌，病毒，寄生虫，甚至癌细胞。目前的提议将扩大我们测试抗体产生定制免疫能力的数量。我们将研究一些新分子将外来物质转运到树突细胞的能力和刺激免疫反应的能力。接下来，我们将测试这些归巢装置作为疫苗及其预防或治疗癌症的能力。我们的目标是为癌症免疫治疗开发一种强大，高效，通用的疫苗接种方法。

Dendritic cells are important sentinel cells of the immune system that orchestrate our immune responses against invading pathogens. There are different types of dendritic cells and they perform different jobs. We have a series of antibodies that can recognise markers on the surface of different dendritic cells populations. We can use these antibodies as homing devices to deliver foreign material to individual dendritic cell subpopulations and thereby manipulate the type of immune response generated. Effectively, we aim to tailor immune responses to fight a particular bacteria, virus, parasite, or even cancer cells. The current proposal will extend the number of antibodies we test for their ability to generate tailored immunity. We will examine a number of new molecules for their ability to shuttle foreign material to dendritic cells and their ability to stimulate immune responses. Next, we will test these homing devices as vaccines and their ability to prevent or treat cancer. Our aim is to develop a robust, highly efficient, generic, vaccination approach for cancer immunotherapy.