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MECHANISM OF HISTAMINE RELEASE

MECHANISM OF HISTAMINE RELEASE
组胺释放机制
批准号:
3917058
负责人:
R SIRAGANIAN
金额:
$0.0万
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:
至

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中文摘要
翻译
肥大细胞和嗜碱性粒细胞释放组胺 作为免疫学机制之一正在被研究 与炎症有关。它也是细胞分泌的模型。 组胺释放剂中使用的是免疫球蛋白E 抗体、过敏性毒素、LHRH多肽和钙离子载体 A23187。以培养的大鼠嗜碱性粒细胞白血病细胞为模型 研究免疫球蛋白E受体和生化变化 在细胞激活过程中。可以获得大量的细胞,用于 已经选择了生化研究和生化变异体 它们在细胞途径的不同位置有缺陷 激活和分泌。
英文摘要
Histamine release from mast cells and blood basophil is being studied as one of the immunological mechanisms involved in inflammation. It is also a model for cell secretion. Among the histamine releasing agents employed are IgE antibody, the anaphylatoxins, LHRH peptides, and the Ca2+ ionophore A23187. Cultured rat basophilic leukemia cells are used as a model for the studies of the IgE receptor and of biochemical changes during cell activation. Large numbers of cells can be obtained for biochemical studies and biochemical variants have been selected which are defective at different sites in the pathway of cell activation and secretion.
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PRODUCTION OF HYBRIDOMAS
PRODUCTION OF HYBRIDOMAS
PRODUCTION OF HYBRIDOMAS
MECHANISMS OF HISTAMINE RELEASE
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