LIPOPROTEIN COMPOSITION AND METABOLISM IN PIMA INDIANS

皮马印第安人的脂蛋白组成和代谢 调查了解脂蛋白代谢的控制和 脂蛋白如何与肥胖、胰岛素抵抗和 心血管疾病。动力学方法已经被开发出来用于 极低密度脂蛋白、低密度脂蛋白和低密度脂蛋白代谢的同步研究 极低密度脂蛋白甘油三酯代谢的短期研究 低密度脂蛋白结合特性的体外评价。对中国传统文化的研究 脂蛋白与胰岛素介导的葡萄糖的关系 处理表明，两者之间存在显著的正相关 极低密度脂蛋白与胰岛素抵抗之间的关系，以及显著的负 高密度脂蛋白浓度与胰岛素抵抗的相关性。 这些相关性在男性中比在女性中更强，而且 彼此独立。当极低密度脂蛋白之间的关系 检测甘油三酯和极低密度脂蛋白载脂蛋白B代谢，数据 提示肥胖者高胰岛素血症或胰岛素 抗药性诱导极低密度脂蛋白载脂蛋白B和超低密度脂蛋白 甘油三酯，而糖尿病患者的极低密度脂蛋白甘油三酯的产生 通过增加血浆中的游离脂肪酸或葡萄糖来刺激。 PIMA的肥胖对女性的高密度脂蛋白有更强的影响， 肥胖女性的高密度脂蛋白的变化与减少有关 血浆雌二醇和肝脂酶活性升高。 我们对高密度脂蛋白的研究表明，高密度脂蛋白的浓度与 性激素以及胰岛素抵抗和 男性和女性在亲属方面可能会有所不同 这些因素的重要性。

Lipoprotein composition and metabolism in Pima Indians are being investigated to understand control of lipoprotein metabolism and how lipoproteins are related to obesity, insulin resistance and cardiovascular disease. Kinetic methods have been developed for the simultaneous study of VLDL, IDL, and LDL metabolism, for the short-term study of VLDL triglyceride metabolism, and for the in vitro evaluation of the binding properties of LDL. Studies of the relationships between lipoproteins and insulin-mediated glucose disposal indicated that there is a significant positive correlation between VLDL and insulin resistance, and a significant negative correlation between HDL concentrations and insulin resistance. These correlations were stronger in men than in women and were independent of each other. When the relationships between VLDL triglyceride and VLDL apoB metabolism were examined, the data suggested that in obese subjects hyperinsulinemia or insulin resistance induces overproduction of both VLDL apoB and triglyceride, whereas in diabetes VLDL triglyceride production is stimulated through increases in plasma free fatty acids or glucose. Obesity in the Pimas had a stronger influence on HDL in women, and the changes in HDL in obese women were associated with decreases in plasma estradiol and increases in hepatic lipase activities. Our studies on HDL suggest that HDL concentrations are related to both sex hormones and also to measures of insulin resistance and that men and women may differ with respect to the relative importance of these factors.