EVALUATIONS OF PROSTHETIC CARDIAC VALVES--IN VIVO EXPERIMENTAL STUDIES

本项目的研究包括正在进行的 活体实验动物模型的建立及应用 用幼羊评估心脏瓣膜的系统。这个 研究本质上是多学科的，使用调查性的 来自外科、生理学、病理学领域的技术 工程和技术开发。会议期间的主要工作重点 一年来：1)关于植入前的疗效的研究 改善钙化的治疗方案 生物瓣膜.2)速度、流量和压力的定义 超声在人工瓣膜中产生的湍流分布 技术；3)流体动力学数据的比较 体内(动物)研究和体外研究获得的研究； 4)老一代(1975年前引入)与 新一代瓣膜；5)比较血流动力学/流体力学 临床或手术中使用的人工瓣膜的研究 临床前评估；6)持续表征 生物假体的形态病理改变 瓣膜；7)手术和术后的改进 管理技巧。

The studies of this project include those of the ongoing development and application of an in vivo experimental animal model system using juvenile sheep for evaluating cardiac valves. The studies are multidisciplinary in nature, using investigative techniques from the fields of surgery, physiology, pathology engineering, and technology development. Major emphases during the year have been: 1) studies of the efficacy of preimplantation treatment regimens upon ameliorating the calcification of bioprosthetic valves; 2) definitions of the velocity, flow and turbulence profiles produced by prosthetic valves using ultrasound techniques; 3) comparisons of fluid dynamic data obtained from the in vivo (animal) studies and those obtained from in vitro studies; 4) comparisons of old generation (introduced prior to 1975) versus new generation - valves; 5)comparative hemodynamic/fluid mechanic studies of prosthetic valves used clinically or undergoing preclinical evaluations; 6) continuing characterization of the morphologic pathologic alterations occurring in bioprosthetic valves; and 7) refinements of operative and postoperative management techniques.