FLUORESCENCE-GUIDED LASER ANGIOPLASTY IN PATIENTS

一种基于荧光光谱的双激光系统样机 结合脉冲染料激光对组织进行斑块识别 利用消融进行荧光引导激光 辅助性球囊血管成形术在股静脉畸形中的应用 闭塞。在10名患者中，我们展示了成功的实时 荧光引导脉冲染料激光消融BUT障碍物 注意到激光和随后的球囊血管成形术都有困难 严重钙化的病变。这一早期的临床经验将 允许我们修改输送系统，以便更大的激光 增加导管尖端可形成血管成形术通道 控制力。 此外，我们已经开始了对患有癌症的患者的初步研究 使用类似荧光技术的慢性冠状动脉完全闭塞 制导激光系统。这将是第一次尝试 经皮激光介入治疗慢性全冠状动脉再通 人类的闭塞和结果即将公布。

A prototype dual laser system employing fluorescence spectroscopy for plaque recognition combined with a pulsed dye laser for tissue ablation was utilized to perform fluorescence guided, laser assisted balloon angioplasty in patients with femoro-popliteal occlusions. In 10 patients, we demonstrated successful real-time fluorescence-guided pulsed dye laser ablation of obstructions but noted difficulty with both laser and subsequent balloon angioplasty of heavily calcified lesions. This early clinical experience will permit us to modify delivery systems such that larger laser angioplasty channels may be created with increased catheter tip control. In addition, we have begun preliminary studies in patients with chronic total coronary occlusions using a similar fluorescence guided laser system. This will be the first attempt at percutaneous laser recanalization of chronic total coronary occlusions in humans and results are forthcoming.