PHARMACOLOGY OF ANXIETY

Maudsley反应性大鼠是Wistar近交系大鼠的品系， 表现出“过度情绪化”，其特征是高发病率， 在空旷的地方被冻死和排便 科廷厄姆医生是 从行为和生化方面对这种菌株进行了鉴定 在我们的动物园中培育的Maudsley Reactives显示出预期的高活性。 在我们的户外视频跟踪中的冻结和排便水平 装置，与Maudsley非反应型和Sprague-Dawley 对照 然而，反应物显示出在生物相容性上没有差异。 习得性无助综合征或t型迷宫记忆模式。 没有 MNR和MR株之间TH的mRNA存在差异 在肾上腺或蓝斑中，在皮质中GAD mRNA中， 海马、小脑或纹状体，或在γ GABA-A受体亚基的表达。 的MR 免疫功能明显受到抑制， T细胞和β细胞增殖的标志物。

The Maudsley Reactive rat is a strain of Wistar inbred rat which shows "hyperemotionality", characterized by a high incidence of freezing and defecation in an open field. Dr. Cottingham is characterizing this strain behaviorally and biochemically. Maudsley Reactives bred in our vivarium showed the expected high levels of freezing and defecation in our open field videotracking apparatus, as compared to Maudsley Non-Reactive and Sprague-Dawley controls. However, the Reactives showed no differences on the learned helplessness syndrome, or on t-maze memory paradigms. No differences between MNR and MR strains were found in mRNA for TH in adrenal gland or locus coeruleus, in mRNA for GAD in cortex, hippocampus, cerebellum, or striatum, or in mRNA for the gamma subunit of the GABA-A receptor in cortex or hippocampus. The MR had a significantly suppressed immune function, as measured by markers for t-cell and beta-cell proliferation.