PARTICULATE DEBRIS FROM ROTATIONAL ATHERECTOMY

旋转式动脉粥样硬化切除导管可消融动脉粥样硬化并修复 动脉粥样硬化动脉的通畅性，但对其知之甚少 由此产生的微粒碎片或其对心肌血液的影响 流。因此，我们检查了颗粒碎片的数量和大小 人尸检主动脉消融后的分布 复杂的激光荧光和光散射粒子 柜台。几乎90%的颗粒小于12微米 尺寸和80%的尺寸小于5微米。要确定 微粒碎屑对心肌血流的急性体内影响， 仔细分级的微粒注射被注入到 测量犬冠状动脉左回旋支及血流量 使用放射性标记的微球。初步结果显示 只有非常大剂量的钙化颗粒才会引起 有害的血液动力学影响。这些研究将继续进行。 为了使我们对安全颗粒负荷的理解正式化 在没有冠状动脉微循环的情况下可以耐受 显著影响心肌血流量和/或左 脑室血流动力学。

Rotational atherectomy catheters can ablate atheroma and restore patency in atherosclerotic arteries but little is known about the resultant particulate debris or its effect on myocardial blood flow. Therefore, we examined particulate debris number and size distribution after ablation of human necropsy aorta utilizing a sophisticated laser fluorescence and light scattering particle counter. Almost 90% of the particles were less than 12 microns in size and 80% were less than 5 microns in size. To determine the acute in vivo effects of particle debris on myocardial blood flow, carefully graded injections of particulate were infused into the left circumflex coronary artery of dogs and blood flow was measured using radio-labeled microspheres. Preliminary results indicate that only very large doses of calcified particulate caused deleterious hemodynamic effects. These studies will be continued to formalize our understanding of the safe particle burden which could be tolerated by the coronary microcirculation without significant effects on myocardial blood flow and/or left ventricular hemodynamics.