PARTICULATE DEBRIS SIZE FROM EXCIMER AND ARGON LASER ABLATION

临床激光血管成形术的可行性取决于安全和 有效清除阻塞的血管内动脉粥样硬化。 但是，不同的激光来源(可见光、红外或紫外线) 并且可变的激光参数(脉冲与连续)导致 不同的组织机制导致不同的组织效应 消融。因为去除动脉粥样硬化后的颗粒碎片可能 导致血液动力学上重要的动脉内血栓事件， 有必要对激光的光产物进行表征 在这些技术可以考虑用于临床之前进行消融 申请。因此，我们确定了其大小分布 激光烧蚀全厚孔后的特殊碎屑 用脉冲紫外线照射生理盐水下的正常尸检大动脉 准分子激光器和连续的氩气激光器。对于这两个激光器 来源：80%以上的颗粒物碎片小于3 微米大小，这表明大多数照相产品 都太小了，不会造成微血管阻塞。有趣的是， 准分子激光，尽管热组织损伤较少，但导致了5- 大于5的粒子数量增加10倍 微米大小。自脉冲准分子激光组织消融以来 产生冲击波，这种组织消融机制可能会导致 在更大的颗粒大小分布中，可能是 不利的。

Feasibility of clinical laser angioplasty will depend upon safe and efficacious removal of obstructing intravascular atheroma. However, different laser sources (visible, infrared, or ultraviolet) and variable lasing parameters (pulsed vs continuous) result in different tissue effects due to different mechanisms of tissue ablation. Since particulate debris after atheroma removal may result in hemodynamically important intraarterial embolic events, it becomes necessary to characterize the photo-products of laser ablation before these techniques can be considered for clinical application. Thus, we determined the size distribution of particular debris after laser ablation of full thickness holes in normal necropsy aorta under saline using a pulsed ultraviolet excimer laser and a continuous argon laser. For both laser sources, more than 80% of particulate debris was less than 3 microns in size, suggesting that the majority of photo-products are too small to cause microvascular obstruction. Interestingly, the excimer laser, despite less thermal tissue injury, caused a 5- 10 fold greater number of particles which are greater than 5 microns in size. Since pulsed excimer laser tissue ablation creates shock waves, this mechanism of tissue ablation may result in a larger particle size distribution which may be disadvantageous.