NEURON-SPECIFIC ENOLASE IN CHILDHOOD TUMORS

儿童实体瘤的诊断和治疗通常是 由于缺乏可辨别的特征而难以辨别。这是 尤文氏肉瘤、神经母细胞瘤、原始软组织尤其如此 肉瘤，以及(偶尔)淋巴瘤。我们已经评估了一种 神经元特异性烯醇化酶(NSE)，在 一组儿童实体肿瘤的石蜡包埋切片， 包括以前未被识别的神经肿瘤变种，使用 用NSE抗血清进行免疫细胞化学。我们发现了均匀的反应性 所有带有这种抗体的神经肿瘤。与非神经性疾病无交叉反应 肿瘤，除了一例罕见的分化型横纹肌肉瘤外，被发现。 我们认为NSE是一种可靠的、易于检测的EVEN标志物。 起源于神经的儿童原始肿瘤。此外，我们还定义了 一种新发现的胸壁“圆形细胞”肿瘤的神经组织发生 类似于尤因的肉瘤，被称为阿斯金瘤，实际上是一种 周围型神经上皮瘤。最后，我们最近确认了 所谓周围神经上皮瘤的独特特征，即 NSE阳性，但显示神经和Schwannian混合形态 性格特征。

The diagnosis, and thus therapy, of solid tumors of childhood is often difficult due to lack of distinguishing characteristics. This is especially true of Ewing's sarcoma, neuroblastoma, primitive soft tissue sarcomas, and (occasionally) lymphoma. We have evaluated the presence of a specific neural enzyme, neurone-specific enolase (NSE), in paraffin-embedded sections of a diverse group of solid childhood tumors, including previously unrecognized variants of neural tumors, employing immunocytochemistry with antisera to NSE. We find uniform reactivity of all neural tumors with this antibody. No cross-reactivity with non-neural tumors, save a rare example of differential rhabdomyosarcoma, was found. We conclude that NSE is a reliable, readily detected marker in even primitive childhood tumors of neural origin. Also, we have defined the neural histogenesis of a newly described, "round cell" tumor of chest wall resembling Ewing's sarcoma, the called Askin tumor, which in reality is a form of peripheral neroepithelioma. Finally we have recently confirmed the unique character of so-called peripheral neuroepithelioma, which is NSE-positive but which displays hybrid neural and Schwannian morphologic chararacteristics.