BIOAVAILABILITY AND TOXICITY STUDIES OF MICROENCAPSULATED CHEMICALS

三氯乙烯（TCE）和2，6-二甲基苯胺，两种挥发性化学品， 分别包封在明胶-山梨醇微胶囊中。 这些 制剂已经显示出为药物提供足够的稳定性， 化学品，使他们可能是有用的剂量饲料毒理学研究。 的 该项目的目标是比较 大鼠和小鼠对纯化学品和微胶囊化化学品的吸收， 评估使用微胶囊作为一种手段的可行性， 将不稳定的试验化学品掺入啮齿动物饲料中进行毒理学研究 问题研究 TCE的吸收速率和程度，无论是作为一种 将微胶囊化三氯乙烯悬浮在玉米油中或作为纯三氯乙烯溶液 通过管饲法对雄性Fischer 344大鼠给予玉米油中的TCE， 研究了 在B6 C3 F1小鼠中进行的类似研究正在开发中。 毒性 微胶囊TCE在大鼠和小鼠中的作用正在研究中。

Trichloroethylene (TCE) and 2,6-xylidine, two volatile chemicals, have been separately encapsulated in gelatin-sorbitol microcapsules. These formulations have been shown to provide sufficient stability to the chemicals so that they may be useful in dosed-feed toxicology studies. The objectives of this project are to compare the rates and extents of absorption of neat and microencapsulated chemicals in rats and mice, and to evaluate the feasibility of using microencapsulation as a means of incorporating unstable test chemicals into rodent feed for toxicology studies. The rates and extents of absorption of TCE, prepared either as a suspension of microencapsulated TCE in corn oil or as a solution of neat TCE in corn oil, administered by gavage to male Fischer 344 rats have been studied. Similar studies in B6C3F1 mice are being developed. The toxicity of microencapsulated TCE in rats and mice is being studied.