LIPID METABOLISM OF THE MACACA FASCICULARIS

本研究将探讨猕猴对外源性脂肪酸的代谢 束状的 真核生物不能合成的反式脂肪酸 将用作外源性脂肪酸标记物。 反式脂肪酸是 顺式脂肪酸的几何异构体，其可以通过以下方法合成： 真核生物 反式脂肪酸是无毒的，只要必需脂肪酸 酸的要求得到满足。 反式脂肪酸被分解代谢， 在从饮食中去除后不久就从体内去除。 本研究将使用12只雄性食蟹猴。 六 这些猴子将被喂食控制饮食，而其他猴子将被喂食 含有反式脂肪酸的实验饮食。 36周将是 需要完成研究。 这项研究的目的是： 1)确定猴子是否具有产生反式所需的肠道植物群 脂肪酸 2)确定反式脂肪酸是否掺入红细胞膜， 猴子。 3)确定反式脂肪酸是否掺入红细胞膜 通过检测膜结合酶来影响膜功能。

The study will examine the metabolism of exogenous fatty acids by Macaca fascicularis. Trans fatty acids which can not be synthesized by eukaryotes will be used as the exogenous fatty acid marker. Trans fatty acids are geometrical isomers of cis-fatty acids which can be synthesized by eukaryotes. Trans fatty acids are not toxic as long as the essential fatty acid requirements are satisfied. The trans fatty acids are catabolize and removed from the body shortly after they are removed from the diet. Twelve male Macaca fascicularis monkeys will be used in the study. Six of the monkeys will be fed the control diet and the others will be fed the experimental diet containing trans fatty acids. Thirty-six weeks will be required to complete the study. The objectives of the study are to: 1) Determine if the monkeys have the gut flora required to produce trans fatty acids. 2) Determine if trans fatty acids are incorporated into the RBC membrane of the monkeys. 3) Determine if the trans fatty acids incorporated into the RBC membrane effect the membrane function by examining a membrane-bound enzyme.