SERUM CHOLESTEROL AND TRIGLYCERIDE VALUES OF THE NCRR WHHL RABBIT COLONY

兽医资源计划，国家研究中心 资源，建立了渡边遗传性高脂血症（WHHL） 兔子繁殖群作为研究人员的资源， 用于由人引起的人类家族性高胆固醇血症的动物模型 低密度脂蛋白受体缺陷。 这样做的目的 项目是评估基因型对血清的影响， NIH WHHL兔的胆固醇和甘油三酯浓度。 于1991年和1994年从WHHL家兔中采集血液。 1991年平均 血清总胆固醇和甘油三酯浓度为828， 394 mg/dl。 血清胆固醇和甘油三酯值 范围分别为310 - 1251 mg/dl和107 - 959 mg/dl。 的 1994年血清总胆固醇值范围为222至1356 mg/dl， 平均值为572 mg/dl。 血清甘油三酯值范围为134至135。 1410 mg/dl，平均值为423 mg/dl。 1994年血清总水平下降 胆固醇是由于WHHL兔一年的浓度较低 与1991年（550 mg/dl）的同龄家兔相比， mg/dl）。

The Veterinary Resources Program, National Center for Research Resources, has established a Watanabe heritable hyperlipidemic (WHHL) rabbit breeding colony as a resource for investigators requiring this animal model for use in human familial hypercholesterolemia caused by a low density lipoprotein receptor defect. The purpose of this project is to evaluate the influence of genotype on the serum cholesterol and triglyceride concentrations of the NIH WHHL rabbits. Blood was collected from WHHL rabbits in 1991 and 1994. The 1991 mean total serum cholesterol and triglyceride concentrations were 828 and 394 mg/dl, respectively. Serum cholesterol and triglyceride values ranged from 310 to 1251 mg/dl and 107 to 959 mg/dl, respectively. The 1994 total serum cholesterol values ranged from 222 to 1356 mg/dl with a mean of 572 mg/dl. Serum triglyceride values ranged from 134 to 1410 mg/dl with a mean of 423 mg/dl. The 1994 decrease in total serum cholesterol is due to lower concentrations in WHHL rabbits one year and older (406 mg/dl) compared to similarly aged rabbits in 1991 (550 mg/dl).