CSF1R in homeostasis and immunity

哺乳动物（如老鼠或人类）基因组中的DNA序列包含一种编码，该编码指定了身体发育和生长的方式。特殊类型的细胞只使用部分基因组来产生它们的功能；例如，红细胞必须产生携带氧气所需的蛋白质（珠蛋白），而肝脏不需要这些蛋白质。该项目涉及破译DNA中的密码，以确保编码特定产品的基因在正确的时间在正确的地点产生。它特别涉及一种模式基因，CSF1R基因，它是巨噬细胞这种大型白细胞的产生和功能所必需的。我们唯一能剖析密码中单个元素的功能的方法就是将它们从基因组中移除。在这个项目中，我们将使用小鼠转基因技术来确定CSF1R发生了什么，我们去掉了控制何时何地产生的部分代码。项目的第二部分应用生成的工具来确定巨噬细胞的功能。这些细胞存在于身体的每个器官中。它们是身体防御感染的一部分，但它们也有助于修复和再生。它们的功能是由CSF1R基因控制的，我们正在开发针对该基因的疗法。小鼠模型将使我们能够识别和测试新的疗法。

The sequence of DNA in the genome of a mammal such as a mouse or a human contains a code that specifies the way that a body develops and grows. Specialised types of cells use only parts of the genome to generate their function; for example a red blood cell must produce the proteins (globin) that are needed to carry oxygen, where these proteins are not needed in the liver. This project is concerned with deciphering the code within DNA that ensures that the genes that code for particular products are produced in the right place at the right time. It deals specifically with a model gene, the CSF1R gene, which is needed for the production and function of large white blood cells called macrophages. The only we can dissect the function of individual elements of the code is to remove them from the genome. In this project we will use mouse transgenic technologies to determine what happens to CSF1R is we take out part of the code that controls where and when it is produced. The second part of the project applies the tools generated to determine the function of macrophages. These cells are found in every organ in the body. They are part of the body's defense against infections, but they also contribute to repair and regeneration. Their function is controlled by the CSF1R gene, and we are developing therapies that target that gene. The mouse models will enable us to identify and test new therapies.