ADHD AND EXECUTIVE FUNCTIONS--RELATION TO LEARNING DISABILITIES

拟议研究的总体目标是使用收敛方法， 更好地了解RD与其精神疾病之间的因果关系 尤其是ADHD。 拟议研究的具体目标 为： 1. 管理注意缺陷多动障碍的措施 （ADHD）和执行功能（EF）的三个不同的人群; 50对MZ和50对DZ双胞胎，其中至少有一个成员 每对阅读禁用（RD）; B）50对的独立样本， MZ和50对DZ双胞胎，其中每对中至少有一个成员 表现出ADHD的症状;以及c）50对MZ和 50对无学习障碍（LD）学校史的DZ双胞胎 或者多动症 2. 进行遗传连锁研究，以确定一个或多个定量 影响ADHD的性状基因座（QTLs）。 3. 测试RD和ADHD之间关联的竞争性解释 使用遗传学和神经心理学分析。 4. 检查RD的其他精神相关因素的发生率和病因 ADHD。

The overall goal of the proposed research is to use converging methods to better understand the causal relation between RD and its psychiatric correlates particularly ADHD. The specific goals of the proposed research are: 1. To administer measures of attention deficit hyperactivity disorder (ADHD) and executive functions (EFs) to three different populations; a) 50 pairs of MZ and 50 pairs of DZ twins in which at least one member of each pair is reading disabled (RD); b) an independent sample of 50 pairs of MZ and 50 pairs of DZ twins in which at least one member of each pair manifests symptoms of ADHD; and c) a comparison group of 50 pairs of MZ and 50 pairs of DZ twins with no school history of learning disabilities (LDs) or ADHD. 2. To perform a genetic linkage study to identify one or more quantitative trait loci (QTLs) influencing ADHD. 3. To test competing explanations for the association between RD and ADHD using genetic and neuropsychological analyses. 4. To examine the rates and etiology of other psychiatric correlates of RD and ADHD.