STUDIES OF PHENOLPHTHALEIN CONTAINING LAXATIVE USE AND NEOPLASIA

工作总结： 许多泻药，显示出明确的致癌活性， 2-最近完成的啮齿动物为期一年的喂养研究， 毒理学计划（NTP）。大约3%的美国老年人 人群每天使用含酚酞的泻药 基础我们将研究含酚酞的关系 泻药使用与卵巢癌和结直肠腺瘤风险 人体内的息肉我们已经建立了合作协议 与主要调查人员一起进行两项正在进行的病例控制 卵巢癌的危险因素研究。在我们的鼓动下，这些 调查人员在调查问卷中插入了一份2页的 添加剂，其允许使用特定的含酚酞的 泻药每项研究将产生大约300例病例和300例对照， 数据将在1999年准备好进行分析。数据收集 结直肠腺瘤危险因素的两项病例对照研究 息肉已经完成。有关于泻药使用的数据 对于这两项研究。我们已经研究了泻药的使用与风险的关系， 在这些数据中。息肉与使用所有 泻药和含酚酞的泻药， 在考虑了饮食和其他风险因素后， 结直肠腺瘤这两项研究的结果是 彼此不一致，但总体上对 使用含酚酞的泻药与 息肉的风险。

Summary of Work: Phenolphthalein, a constituent in many laxatives, showed clear evidence of carcinogenic activity in 2-year feeding studies in rodents recently completed by the National Toxicology Program (NTP). About 3% of the older U.S. population uses phenolphthalein-containing laxatives on a daily basis. We will investigate the relation of phenolphthalein-containing laxative use with risk of ovarian cancer and adenomatous colorectal polyps in humans. We have established collaborative agreements with the principal investigators for two ongoing case-control studies of risk factors for ovarian cancer. At our instigation, these investigators have inserted into their questionnaire a 2-page addition that ascertains use of specific phenolphthalein-containing laxatives. Each study will yield about 300 cases and 300 controls, and the data will be ready for analysis in 1999. Data collection for two case-control studies of risk factors for adenomatous colorectal polyps have been completed. Data on laxative use were available for both studies. We have examined laxative use in relation to risk of polyps in these data. The association of polyps with use of all laxatives and phenolphthalein-containing laxatives was specifically explored after taking into account dietary and other risk factors for colorectal adenomas. Results from the two studies were inconsistent with each other but overall offered little support for an association between phenolphthalein-containing laxative use and risk of polyps.