Household Transmission and Immunity to SARS-CoV-2 among Paediatric Clients of a Primary Care Center in a Low-resource Community in Rio de Janeiro

我们的目的是研究巴西里约热内卢一个贫民窟中SARS-CoV-2的家庭传播动态，并估计研究人群对这种新病毒的免疫力。我们将对儿童及其家庭样本进行SARS-CoV-2检查和测试。招聘工作将在位于该市最贫穷街区之一的一个初级保健诊所进行。我们将招募0至13岁的儿童，他们被带到诊所接受免费疫苗接种。在获得儿童监护人的书面知情同意后，我们将收集研究样本。之后，我们将到儿童家中收集所有居民的样本，第一个月随访四次，第一年每三个月随访一次，第二年随访两次。我们希望揭示儿童在疾病传播中的作用。

Our aim is to study the household transmission dynamics of SARS-CoV-2 in a slum in Rio de Janeiro, Brazil and to estimate the immunity of the study population against the new virus. We will examine and test a sample of children and their families for SARS-CoV-2.Recruitment will take place at a primary health clinic, located in one of the poorest neighbourhoods of the city. We will recruit children 0 to 13 years of age who are brought to the clinic to receive free vaccinations. With the written informed consent from the child's guardian, we will collect the study samples. Afterwards we will visit the child's home to collect samples of all residents, with four follow-up visits in the first month, every three months during the first year and twice in the second year. We hope to uncover the role of children in the disease transmission.