Development of Platelet-Targeted Nanoparticles for Magnetic Resonance Imaging towards the Detection of Thrombi/Emboli and Vulnerable Atherosclerotic Plaques

心脏病发作、中风和肺栓塞通常在没有警告的情况下发作，要么导致患者死亡，要么造成毁灭性的残疾。目前，我们没有诊断方法来识别患者和处于危险中的血管。我们开发了一种新的针对激活的血小板的创新磁共振纳米颗粒，用于检测处于危险状态的�血管。目前要求的资金是为了优化这种靶向核磁共振纳米颗粒的制造，并进行进入早期临床试验所需的动物研究。

Heart attack, stroke and pulmonary embolism typically strike without warning and either kill patients or cause devastating disabilities. Currently, we do not have diagnostic methods to identify patients and the blood vessels at risk. We have developed a new innovative MRI nanoparticle directed against activated platelets for the detection of _at risk� blood vessels. The current funding is requested to optimise the manufacture of this targeted MRI nanoparticle and to undertake the animal studies required to enter early stage clinical trials.