CHROMOSOME METABOLISM AND CANCER

这是一个培训学生项目的竞争性续签申请 对染色体结构和染色体结构之间的关系进行基础研究 癌症。为了延续我们过去的计划，我们要求提供津贴 四名博士后级别的实习生。此外，我们正在 为博士前水平的培训申请三笔津贴。这个 博士前津贴要求是适当的，因为哈钦森中心 最近被授权授予分子和细胞学博士学位 华盛顿州高等教育协调委员会的生物学 (1993年9月1日批准)。该中心最近还进入了一个 与华盛顿大学签订的附属协议(1994年7月1日) 并开始了分子和细胞生物学联合的第一年 研究生课程与1994年9月入学的班级。 培训将由14名调查人员组成的教员进行 其中一些人是弗雷德·哈钦森基金会基础科学部的成员 癌症研究中心。每一位教员都是公认的专家。 或她自己的领域，并拥有广泛的成功培训记录 包括本科生和研究生。该计划的一个优势是 教师们正在研究的癌症相关模型系统的多样性， 从细胞周期的遗传学到转录本的酶学 离子的引发和终止。 博士前实习生将从高质量的人才库中挑选出来 研究生课程每年录取的学生。一年级学生 最初在三个不同的实验室轮换， 在选择导师之前，哈钦森中心和大学 做论文研究。兴趣与癌症有关的学生 将优先得到拟议计划的支持。 博士后实习生是从全国申请者中挑选出来的。在……里面 除了沉浸在他们选择的研究主题之外，这两组人 的学员被鼓励参与 基础科学部。这包括专业期刊俱乐部、联合 实验室会议，以及外部定期举行的一系列研讨会 扬声器。此外，受训者需要展示他们自己的 定期在小组会议和 在一个更正式的每周研究研讨会上， 组织。这种类型的培训已被证明是有效的 培养能够独立、有创造力的年轻调查人员 癌症分子基础的科学研究。

This is a competitive renewal application for a program to train students to do basic research in the association between chromosome structure and cancer. In continuation of our past program, we are requesting stipends for four trainees at the postdoctoral level. In addition, we are requesting three stipends for training at the predoctoral level. The predoctoral stipend request is appropriate due to the Hutchinson Center's recent authorization to grant the Ph.D. degree in Molecular and Cellular Biology by the State of Washington Higher Education Coordinating Board (granted September 1, 1993). The Center also recently entered an affiliation agreement with the University of Washington (July 1, 1994) and began the first year of the joint Molecular and Cellular Biology Graduate Program with the entering class of September 1994. Training will be performed by a faculty of fourteen investigators, all of whom are members of the Basic Sciences Division of the Fred Hutchinson Cancer Research Center. Each faculty member is a recognized expert in his or her own field and has an extensive record of successful training at both the graduate and postgraduate levels. A strength of the program is the diversity of cancer-related model systems under study by the faculty, ranging from genetics of the cell cycle to the enzymology of transcript ion initiation and termination. Predoctoral trainees will be selected from the pool of high quality students admitted yearly to the graduate program. First year students initially rotate through three different laboratories at both the Hutchinson Center and the University before choosing a mentor with whom to do thesis research. Students whose interests are related to cancer will be given priority to be supported by the proposed program. Postdoctoral trainee are selected from a national pool of applicants. In addition to becoming immersed in their chosen research topic, both groups of trainees are encouraged to participate in the intellectual life of the Basic Sciences Division. This includes specialty journal clubs, joint laboratory meetings, and a regular series of seminars by outside speakers. In addition, trainees are expected to present their own findings at regular intervals, both in small group meetings as well as in a more formal weekly research seminar that is attended by the entire Division. This type of training has been shown to be effective in producing young investigators who are capable of independent, creative scientific research in the molecular basis of cancer.