THREE DIMENSIONAL TOMOGRAPHIC ANGIOGRAPHY

描述：识别将从特定治疗中受益的患者 治疗程序需要准确评估的严重程度， 狭窄、其几何形状和空间方向。 大多数治疗性 目前的决策是基于通过数字技术获得的信息。 减影血管造影术 标准血管造影图像不提供 血管造影师有足够的信息需要作出治疗 决策 这个为期四年的项目的长期目标是不断发展一个 三维（3-D）断层扫描（称为体积断层扫描）数字 血管造影成像技术提供有用的三维血管图像需要 做出诊断和治疗决定。 容积层析数字血管造影（VTDA）结合容积层析成像 成像原理与数字血管造影的成像原理相同。 VTDA只需要一个 单次静脉造影剂注射和容积扫描， 描述头颈部血管解剖结构和狭窄。 这种VTDA技术将上级传统的血管造影术， 强大的临床影响，因为它将提供一个直接的，明确的， 狭窄和其他不规则的精确3D测量， 畸形，包括口径，几何形状和空间方向，而 减少了手术的侵入性、造影剂的量 所需时间、手术时间和总X射线暴露量。 VTDA继续通过计算机模拟进行开发和验证， 体模和在旋转体积断层扫描上进行的动物研究 使用硒薄膜晶体管（STFT）阵列的成像器或成像器 增强器（II）耦合到作为检测器的电荷耦合器件（CCD）。 具体而言，拟议研究的目的是：1）进行研究， 通过计算机模拟优化VTDA; 2）优化锥束 血管重建算法; 3）使用升级的基于II的VTDA系统 开发和评估新的扫描模式，并开发基于STFT的 用于最终静脉内造影剂注射的原型成像系统; 4） 进行体模研究，以验证VTDA技术并优化 系统性能;以及5）使用原型成像器用于动物 实验作为人类研究的前奏;以及6）进行临床研究 基于优化注射和体积的颈部和脑部研究 在动物研究中开发的扫描协议。

DESCRIPTION: Identification of patients who will benefit from a specific therapeutic procedure requires the accurate assessment of the severity of stenoses, their geometry and spatial orientation. Most therapeutic decisions are currently based on information obtained through digital subtraction angiography. Standard angiographic images are not providing angiographers with sufficient information needed to make therapeutic decisions. The long-term goal of this four year project is to continually develop a three-dimensional (3-D) tomographic (called volume tomographic) digital angiography imaging technique to provide useful 3-D vascular images needed for diagnostic and therapeutic decisions. Volume tomographic digital angiography (VTDA) combines volume tomographic imaging principles with those of digital angiography. VTDA requires only a single intravenous contrast injection and volume scan to provide a true description of vascular anatomy and stenoses in head and neck. This VTDA technique will be superior to conventional angiography and have a strong clinical impact because it will provide a direct, unambiguous and accurate 3D measurement of stenoses and other irregularities and malformations, including caliber, geometry and spatial orientation, while reducing the invasiveness of the procedure, the amount of contrast media required, procedure time and total X-ray exposure. VTDA continues to be developed and validated through computer simulation, phantom, and animal studies performed on a rotational volume tomographic imager that uses a selenium thin film transistor (STFT) array or an image intensifier (II) coupled to a charge-coupled device (CCD) as a detector. Specifically, the aim of the proposed research is: 1) to perform studies on optimization of VTDA through computer simulation; 2) to optimize cone beam vascular reconstruction algorithms; 3) use the upgraded II-based VTDA system to develop and evaluate new scanning modes and develop the STFT-based prototype imaging system for ultimate intravenous contrast injection; 4) to perform phantom studies to validate the VTDA technique and optimize the system performance; and 5) to use the prototype imager for animal experiments as a prelude to human studies; and 6) to perform the clinical studies in neck and brain based on the optimized injection and volume scanning protocols developed in animal studies.