STUDY OF SOCIAL AND COGNITIVE ASPECTS OF SCHIZOPHRENICS

这个项目使用实验心理学技术来检验 精神分裂症患者的眼动、认知和社交功能是否 任务是由于抑制不适当的能力受损而导致的 与前额叶皮层功能障碍相关的反应， 大脑区域数据收集来自我们的核心样本65个药物 精神分裂症患者和44名正常人的配对就完成了但是，我们， 继续测试受试者在两个药物和药物 自由州今年，为了阐明 药物治疗的心理作用，并探讨 典型和非典型神经抑制剂之间的差异，我们开发了一些 新的实验程序， 选择性注意和负启动。我们还修改了 精神分裂症患者使用一种重要的新的实验性工作方法， 记忆容量 此外，我们继续准备数据进行分析 并对已经准备好的数据进行分析。今年我们付出了 特别注意眼球运动中涉及的复杂问题 测量.第一篇基于我们的眼动数据的论文被接受了 发表在一家主要期刊上。它比较了 在扫视和手动反应时间（RT）测试的前期变化。 尽管手动RT显示出精神分裂症特有的缓慢性， 夸大的前期效应，我们之间没有发现差异， 精神分裂症和正常受试者的扫视RT性能。这些 结果提出了关于RT缺陷的主要问题， 精神分裂症的特征 较早的具有重要理论意义的结果于2000年发表， 年，在一份重要的期刊上。这些发现表明，“看不见”是 精神分裂症患者的“精神失常”，并通过以下方式确认死亡： Goldman-Rakic关于前额叶皮质功能障碍对大脑皮层的影响 精神分裂症患者的工作记忆

This project uses experimental psychological techniques to examine whether schizophrenic deficits in ocular-motor, cognitive and social tasks result from an impaired ability to suppress inappropriate responses linked to dysfunction of the prefrontal cortex and related brain areas. Data collection from our core sample of 65 medicated schizophrenics and 44 matched normals is complete. We are, however, continuing to test subjects available in both a medicated and a drug free state. This year, in order to elucidate the nature of the psychological effects of pharmacological treatments and to explore differences between typical and atypical neuroleptics, we developed some new experimental procedures that finely examine the temporal dimensions of selective attention and negative priming. We have also modified for use by schizophrenics an important new experimental measure of working memory capacity. In addition, we continued the tasks of preparing our data for analysis and carrying out analyses of already prepared data. This year we paid particular attention to the complex issues involved in eye-movement measurement. The first paper based on our eye-movement data was accepted for publication in a major journal. It compared the effects of foreperiod variations in saccadic and manual reaction time (RT) tests. Although manual RT showed the characteristic schizophrenic slowness and exaggerated foreperiod effects, no differences were found between our schizophrenic and normal subjects in saccadic RT performance. These results raise major questions about the locus of the RT deficits seen as characteristic of schizophrenia. Earlier results of substantial theoretical import were published this year in a major journal. These findings suggest that "out of sight" is "out of mind" for schizophrenic individuals and confirm conjectures by Goldman-Rakic about the effects of prefrontal cortex dysfunction on the working memory of schizophrenic individuals.