DETECTION OF ARTERIAL WALL DISORDERS BY MRI

描述 申请人的长期职业目标是成为独立的 磁共振成像（MRI）领域的研究者， 我想集中精力提高诊断能力 以及对MRI与肿瘤之间关系的理解 参数和人体病理生理学（重点是心血管 问题）。 因此，所提出的应用程序的目标是获得动手 通过开发MRI在临床MRI技术方面的经验 用于体内检测动脉中结构变化的技术 与病理状态相关的壁，例如动脉粥样硬化， 动脉瘤扩张和高血压。 该项目的重点是 发展MRI方法检测内膜下脂质沉积和MRI 方法，可以准确地检测水成分的变化， 人类的动脉壁。 水抑制，基于不同的 扩散特性、自旋-晶格弛豫时间和化学位移 在脂质和水旋转之间，将用于内膜下成像 脂质。 这些技术将用于对患有以下疾病的患者进行成像： 动脉粥样硬化 精确测量自旋-自旋弛豫的MRI方法 (T2)磁化转移的程度和扩散将被实施， 对动脉壁的水成分成像。 扩散各向异性 动脉壁将通过MRI测量， 膨胀，以估计组织的程度， 弹性蛋白/胶原基质。 自旋-自旋弛豫时间的变化， 磁化转移和扩散将在高血压和 血压正常的个体，并与主动脉顺应性和严重程度相关 疾病。 根据变化解释MRI参数的变化 在动脉壁的结构中，由于高血压， 将高血压大鼠（SHR）用作高血压动物模型。 MRI 测量将在SHR和血压正常的动脉中进行 大鼠和相关的在体内动脉被动力学测量 以及动脉壁的组成。 该项目将进行 在亚瑟F. Gmitro博士，一个物理学家 在医学成像方面有着丰富的经验，史蒂文·戈德曼教授， 医学博士，在临床研究方面具有丰富经验的心脏病专家。 最 该项目将在临床MRI和生物NMR进行 亚利桑那大学的设施，申请人将在那里工作 在MR技术专家、心脏病专家、放射科医生和 生理学家 为了获得研究所需的背景资料， 在项目的培训部分，申请人将参加医疗课程 成像，电子学和生理学在第一年的赠款。

DESCRIPTION The applicant's long-term career goal is to become an independent investigator in the field of magnetic resonance imaging (MRI) where she would like to concentrate her efforts to improve the diagnostic capability of the technique and understanding of the relationship between MRI parameters and human pathophysiology (with emphasis in cardiovascular problems). Thus, the goal of the proposed application is to gain hands-on experience in the technical aspects of clinical MRI by developing MRI techniques for the in vivo detection of structural changes in the arterial wall associated with pathological states, such as atherosclerosis, aneurysmal dilation, and hypertension. The project focuses on the development of MRI methods to detect subintimal lipid deposits and MRI methods that can accurately detect changes in the water component of the arterial wall in humans. Water-suppression, based on the differences in diffusion properties, spin-lattice relaxation times, and chemical shift between lipid and water spins, will be implemented for imaging subintimal lipids. These techniques will be used to image patients with atherosclerosis. MRI methods to accurately measure spin-spin relaxation (T2), extent of magnetization transfer, and diffusion will be implemented to image the water component of the arterial wall. The diffusion anisotropy of the arterial wall will be measured by MRI in patients with aneurysmal dilation in order to estimate the degree of organization of the elastin/collagen matrix. Changes in spin-spin relaxation times, extent of magnetization transfer, and diffusion will be measured in hypertensive and normotensive individuals and correlated with aortic compliance and severity of disease. To interpret the changes in MRI parameters in terms of changes in the structure of the arterial wall due to hypertension, the spontaneous hypertensive rat (SHR) will be used as an animal model of hypertension. MRI measurements will be carried out in the arteries of SHR and normotensive rats and correlated with in vivo arterial passive mechanical measurements and with the composition of the arterial wall. The project will be carried out under the sponsorship of Professor Arthur F. Gmitro, Ph.D., a physicist with extensive experience in medical imaging, and Professor Steven Goldman, M.D., a cardiologist with extensive experience in clinical research. Most of the project will be carried out at the Clinical MRI and Biological NMR facilities at the University of Arizona where the applicant will be working in an environment with MR technologists, cardiologists, radiologists, and physiologists. To obtain the necessary background for the research and training parts of the project, the applicant will take courses in medical imaging, electronics, and physiology during the first years of the grant.