HERITABILITY & GENETIC MARKERS OF BONE STRENGTH AND BONE TURNOVER

与年龄相关的骨质疏松性骨折在很大程度上是由于 随着年龄增长而产生的骨骼强度。大约80%的骨骼变异 密度，这是骨骼强度的主要决定因素，是由白人决定的。 遗传因素的影响。虽然大家都知道黑人的骨骼更高 密度和骨折发生率低于白人，骨的遗传力 黑人的力量还没有被研究过。基因的鉴定 负责确定黑人内部和黑人之间的骨骼强度 白人将代表着早期人口识别的重要一步 面临骨折风险，并开发新的预防和治疗方法 老年性骨质疏松症的治疗方案。

Age-related osteoporotic fracture is in large part due to the reduction in bone strength that occurs with age. About 80% of the variance in bone density, which is the main determinant of bone strength, is due in whites to heritable factors. Although it is known that blacks have a higher bone density and lower fracture incidence than whites, heritability of bone strength has not been studied in blacks. Identification of the genes responsible for determining bone strength within and between blacks and whites would represent a major step in early indentification of population at risk of fracture and in developing new approaches to preventative and therapeutic regimens for age-related osteoporosis.