YOHIMBINE CHALLENGE TO STUDY NORADRENERGIC FUNCTION IN INDIVIDUALS

家庭暴力是影响 社会。我们的研究结果表明，那些 身体虐待他们的另一半经常经历 在暴力行为发生时处于极度兴奋状态 特点是运动活动增加，自主神经增强 神经系统活动，并伴随着“出局”的感觉 这种高度兴奋的状态与发生的情况类似 创伤后应激障碍(PTSD)。自从创伤后应激障碍 与去甲肾上腺素能功能的变化有关，(1)我们假设 失控和身体暴力的受试者也可能 有异常的去甲肾上腺素功能。为了检验这一假设，我们 我设计了一项研究，比较了行为和 α-2给药引起的生化效应 拮抗剂，育亨宾在一群失控的患者之间 并且是身体暴力和非暴力的对比对象。至 到目前为止，还没有出现任何不良影响。将对结果进行分析 当积累了足够多的主题以允许有意义的 结果。

Domestic violence is a major problem affecting society. Results from our research show that individuals who are physically abusive to their significant other frequently experience a hyperaroused state at the time of the violent act which is characterized by increased motor activity, heightened autonomic nervous system activity and accompanied by feelings of "being out of control". This hyperaroused state is similar to that which occurs in Post Traumatic Stress Disorder (PTSD). Since PTSD has been associated with changes in noradrenergic function, (1) we postulate that subjects who lose control and are physically violent may also have abnormal noradrenergic function. To test this hypothesis, we have designed a study which compares the behavioral and biochemical effects resulting from the administration of the alpha-2 antagonist, yohimbine between a group of patients who lose control and are physically violent and non-violent comparison subjects. To date there have been no untoward effects. Results will be analysed when sufficient subjects have been accrued to allow meaningful results.