POWER TO DETECT LINKAGE IN GENOMIC SCREENS USING MOVING AVERAGE TEST STATISTICS

当使用连锁分析对复杂性状进行基因组筛选时，可以确定两点连锁分析产生适度p值的区域，单独使用这些p值不会被认为是连锁的暗示。一种方法是将来自相关标记簇的信息组合成地区性的？联动试验。研究了两类区域连锁检验统计量在不同遗传力范围和不同标记集上的性质。第一类包括来自连续标记集合的最小t值，第二类包括t统计量的移动平均值。基于10厘米图的初步结果表明，要求连续两次t检验显著的最小-t统计量的威力比两点检验有所提高。观察到连续2至5个t检验值的移动平均值的较大收益。对于遗传力在30%到60%之间的遗传力，检测连锁的能力增加了5%到20%。还考虑了一种类似于等级检验的新的特殊检验过程，其统计性质正在进一步研究中。-计算机模拟、G.A.S.P.、基因计量学、连锁分析、同胞对连锁分析、区域测试统计、移动平均值

When using linkage analysis to perform genomic screening for complex traits, regions may be identified where two-point linkage analysis produces modest p-values that, taken individually, would not be considered to be suggestive of linkage. One approach is to combine information from correlated clusters of markers into ?regional? tests of linkage. The properties of two classes of regional linkage test statistics were investigated over a range of heritabilities and different marker sets. The first class included minimum t values from sets of consecutive markers, the second included moving averages of the t-statistics. Initial results, based on a 10 cM map, suggest that the power for the min-t statistic, requiring that two consecutive t-tests be significant, was increased over two-point tests. Larger gains were observed for moving averages of 2 to 5 consecutive t-test values. The gains in power to detect linkage ranged between 5 and 20% for heritabilities between 30% and 60%. A novel ad hoc test proceedure analagous to a rank test was also considered, and its statistical properties are being investigated further. - computer simulation, G.A.S.P., genometrics, linkage analysis, sib-pair linkage analysis, regional test statistics, moving averges