PLANNING GRANT FOR A MULTIPURPOSE CLINICAL RES CENTER

这项计划补助金要求资源，以协助准备在风湿性疾病的多功能临床研究中心。 该提案的总体目标是促进系统性红斑狼疮、类风湿性关节炎、炎性肌炎和韦格纳肉芽肿的高质量临床研究。 实现这一目标的具体计划是确定，巩固和增加必要的资源，以连接我们的基础科学和临床研究领域，建立一个专门的生物统计和研究设计核心风湿性疾病的研究，并创建一个有竞争力的，统一的多用途临床研究中心的应用。俄克拉荷马州医学研究基金会的优势，这种性质的规划赠款是多方面的。 站在最前沿的是莫里斯·赖希林博士作为项目总监的领导。 Reichlin博士被公认为风湿性疾病自身抗体研究的领导者，数十年来一直致力于风湿性疾病的临床研究。 Reichlin博士领导了一个关节炎和免疫学项目，致力于并从事高水平的临床研究，特别是在人类SLE的遗传学，人类狼疮和肌炎自身抗体的发展和发病机制，自身抗体在儿科风湿性疾病中的作用。 俄克拉荷马州医学研究基金会还在免疫遗传学、免疫生物学和心血管生物学方面拥有世界一流的生物医学/基础科学项目。俄克拉荷马州医学研究基金会和俄克拉荷马州大学健康科学中心都提供了强有力的机构支持。俄克拉荷马州有很多独特的机会。 我们的研究基地超过三分之二的农村性质，位于美国中部地区，并有少数民族的个人，特别是美国印第安人的比例很高。这项提议将提供资源，以实现下列具体目标：1）加强生物统计学/研究设计能力，并将这些流行病学/生物统计学方法纳入我们目前的人类研究项目2）开发临床数据库，以扩大我们的血清学知识库，3）加强和规范与基础科学计划的互动，4）更好地将项目相互关联，以组成临床研究中心。

This planning grant requests the resources to assist in preparing for a multipurpose clinical research center in rheumatic diseases. The overall goal of this proposal is to promote high quality clinical research in systemic lupus erythematosus, rheumatoid arthritis, inflammatory myositis and Wegener's granulomatosus. The specific plans to accomplish this goal are to identify, consolidate and augment the necessary resources to interconnect our basic science and clinical research areas, to establish a specialized biostatistic and research design core for rheumatic disease research and to create a competitive, unified multipurpose clinical research center application. The strengths of the Oklahoma Medical Research Foundation for a planning grant of this nature are multiple. At the forefront is the leadership of Dr. Morris Reichlin as the Program Direct. Dr. Reichlin is recognized as a leader in the study of rheumatic disease autoantibodies and has been committed to rheumatic disease clinical research for decades. Dr. Reichlin leads an Arthritis and Immunology program which is dedicated to and engaged in high-caliber clinical research, especially in the genetics of human SLE, the development and pathogenesis of human lupus and myositis autoantibodies, the role of autoantibodies in pediatric rheumatic disease. The Oklahoma Medical Research Foundation also has world class biomedical/basic science programs in Immunogenetics, Immunobiology and Cardiovascular Biology. Strong institutional support is provided both from the Oklahoma Medical Research Foundation and the Oklahoma University Health Sciences Center. Unique opportunities abound in Oklahoma. Our research base is over two-thirds rural in nature, is located in the central region of the United States, and has a high proportion of minority individuals, especially American Indians. This proposal will provide the resources to accomplish the following specific aims: 1) to strengthen the biostastical/research design capabilities and integrate these epidemiologic/biostastical methods into our current human research projects 2) to develop a clinical database to augment our serologic repository, 3) to strengthen and formalize interactions with basic science programs and 4) to better interrelate projects to comprise a clinical research center.