LABORATORY ANIMAL MODELS

鹿鼠是北美数量最多、分布最广的本土啮齿动物。因此，它们对人类健康的许多方面都有影响，因为它们是传染病生物体的储存库，也是生物医学研究中有用的实验室模型。鹿鼠自本世纪初以来一直被圈养，并被广泛用于生理、环境和其他研究。南卡罗来纳大学的Permyscus遗传库中心建议扩大Permyscus的利用，并改进这些动物，将其作为健康相关研究的便利模型。将专门开发六个或更多的Permyscus种群，用于研究汉坦病毒、埃立克体病和这些动物作为宿主的其他疾病，以及各种其他生物医学研究项目。这一动物模型的实用性将通过内部生殖研究来提高，包括配子的循环保存和进一步的遗传特征。开发的库存将提供给科学界用于研究和教育目的。

The deer mouse (Peromyscus maniculatus) and congeneric species are the most abundant and widely distributed native rodents in North America. As a consequence they impact on many aspects of human health as reservoirs for infectious disease organisms and as laboratory models useful in biomedical research. Deer mice have been maintained in captivity since early in the century and are widely used in physiological, environmental and other studies. The Peromyscus Genetic Stock Center at the University of South Carolina proposes to expand utilization of Peromyscus and improve these animals as a convenient model for health-related research. Six or more Peromyscus stocks will be developed specifically for the study of hantavirus, ehrlichiosis and other diseases for which these animals are hosts, as well as for a variety of other biomedical research projects. Utility of this animal model will be improved through in-house studies of reproduction, including cyropreservation of gametes, and further genetic characterization. The stocks developed will be available to the scientific community for research and educational purposes.