TRAINING PROGRAM IN MOLECULAR CELL BIOLOGY OF CANCER

分子细胞生物学和结构生物学的方法和范式在分子水平上将结构和功能与完整细胞的行为联系起来，无论是单独的还是作为多细胞有机体器官系统的一部分。在人类癌症研究所需要的多学科方法中，这一观点是最必要的，也是潜在的更有用的。癌症分子细胞生物学的培训计划利用了基梅尔癌症研究所的选定教员，该研究所是一群有成就的科学家，他们在确定细胞功能和生长控制的正常机制及其在肿瘤中的紊乱方面有着共同的兴趣。培训计划的目标是为有抱负的研究人员提供必要的培训和经验，使他能够作为独立的科学调查人员开始职业生涯，并定位于人类肿瘤学的研究问题。培训计划的博士前学生将从分子药理学和结构生物学博士计划的注册学生中挑选出来，该计划的主要重点是分子细胞生物学，因为它适用于人类肿瘤学。博士前学生必须完成一系列严格的研究生课程，使他们在生物化学、分子生物学和细胞生物学方面有一个全面的背景。这种教学课程之后是更专业的课程，既包括博士课程，也包括托马斯·杰斐逊大学研究生院的其他研究生课程。研究需要在具有不同兴趣的研究导师的实验室中完成三次轮换，并向教职员工介绍一系列研讨会。通过研究咨询委员会和研究生学习指导委员会，学生可以根据以前的经验或特定的兴趣来调整他/她的课程。参加本培训计划的时间不得早于研究生学习的第一年结束。获得博士学位的学习计划对持有认可机构学士学位并希望进入生物医学研究而不成为医生的学生开放，也对持有专业学位(M.D.、D.O.、D.V.M.或D.D.S.)的个人开放。他们希望以独立的科学研究人员的身份从事学术生涯。申请者必须具有扎实的生物和化学科学背景。以前的研究经验是非常可取的。只有全日制学生才能入学。平均绩点、GRE成绩、推荐信、研究兴趣声明和面试都是录取的重要标准。博士后申请者必须拥有博士、医学博士、法学博士、法学博士或医学博士学位。每个学员的计划将取决于过去的研究和教育经验。该计划的目标是培养训练有素、技术能力强的研究科学家，他们能够执行并最终指导癌症分子细胞生物学的研究。

The approaches and paradigms of molecular cell biology and structural biology have been rewarding in relating structure and function at the molecular level to the behavior of the intact cell, either alone or as part of organ systems in the multi-cellular organism. Nowhere is this perspective more necessary or potentially more useful than in the multi- disciplinary approach that is required in the study of human cancer. The Training Program in the Molecular Cell Biology of Cancer utilizes selected faculty of the Kimmel Cancer Institute, a group of accomplished scientists who share related interests in defining the normal mechanisms of cellula function and growth control and their derangement in neoplasia. The goal of the Training program is to provide aspiring researchers with the training and experience necessary for him to launch careers as independent scientific investigators with an orientation toward research questions in human oncology. Predoctoral students in the Training Program will be drawn from those enrolled in the Molecular Pharmacology and Structural Biology Ph.D. Program, which has a major focus on molecular cell biology as it applies to human oncology. Predoctoral students must complete a rigorous series of graduate courses giving them a thorough background in biochemistry, molecular biology and cell biology. This didactic curriculum is then followed by more specialized courses both within the Ph.D. Program and available through the other Graduate Programs in the College of Graduate Studies of Thomas Jefferson University. Studies are required to complete three rotations in the laboratories of research preceptors with diverse interests and also present a series of seminars to the faculty. Research Advisory Committee and the supervisory, Graduate Studies Committee, the student may tailor his/her curriculum depending on prior experience or specific interests. Appointments to this Training Program are made no earlier than the conclusion of the first year of graduate study. The program of study leading to a Ph.D. degree is open to students who hold a Bachelor's degree from an accredited institution who wish to enter biomedical research without become a physician, as well as to individuals holding profession degrees (M.D., D.O., D.V.M. or D.D.S.) who wish to make academic careers as independent scientific investigators. Applicants must have a solid background in the biological and chemical sciences. Previous research experience is highly desirable. Only full-time students are accepted. Grade point average, GRE scores, letters of recommendation, statement of research interest and an interview are all important criteria for acceptance. Postdoctoral applicants must hold a Ph.D., M.D., D.O., D.D.S., or D.V.M. degree. Each trainee's program will depend of past research and educational experience. The goal of this Program is to develop highly trained, technically competent research scientists capable of performing and eventually directing research in the molecular cell biology of cancer.