STUDIES OF PHENOLPHTHALEIN CONTAINING LAXATIVE USE AND NEOPLASIA

目的：在最近由国家毒理学计划（NTP）完成的为期2年的啮齿动物喂养研究中，许多泻药中的一种成分酚酞显示出明确的致癌活性。大约3%的美国老年人每天使用含酚酞的泻药。我们将调查含酚酞泻药的使用与卵巢癌和人类腺瘤性结直肠息肉的风险的关系。成果：我们与主要研究者就卵巢癌危险因素的两项病例对照研究达成了合作协议。在我们的鼓动下，这些调查人员在他们的问卷中插入了一份两页的附加内容，以确定特定含酚酞泻药的使用情况。第一项研究的报告正在出版，其余研究（300个病例和300个对照）的数据将在2000年准备好供分析。新闻报道显示含酚酞泻药的使用与卵巢癌风险没有关联，我们从两项关于腺瘤性结直肠息肉危险因素的病例对照研究中获得了泻药使用的数据。我们在这些数据中检查了泻药的使用与息肉风险的关系。在考虑了饮食和结直肠腺瘤的其他危险因素后，专门探讨了息肉与使用所有泻药和含酚酞泻药的关系。两项研究的结果彼此不一致，但总的来说，几乎没有证据支持含酚酞泻药的使用与息肉风险之间的联系。该报告发表于1997年。

Aims: Phenolphthalein, a constituent in many laxatives, showed clear evidence of carcinogenic activity in 2-year feeding studies in rodents recently completed by the National Toxicology Program (NTP). About 3% of the older U.S. population uses phenolphthalein-containing laxatives on a daily basis. We will investigate the relation of phenolphthalein-containing laxative use with risk of ovarian cancer and adenomatous colorectal polyps in humans. Accomplishments: We established collaborative agreements with the principal investigators for two case-control studies of risk factors for ovarian cancer. At our instigation, these investigators inserted into their questionnaire a 2-page addition that ascertains use of specific phenolphthalein-containing laxatives. A report from the first such study is in press and data from the remaining study (300 cases and 300 controls) will be ready for analysis in 2000. The report in press shows no association of phenolphthalein-containing laxative use and risk of ovarian cancer Data on laxative use were available to us from two case-control studies of risk factors for adenomatous colorectal polyps. We examined laxative use in relation to risk of polyps in these data. The association of polyps with use of all laxatives and phenolphthalein-containing laxatives was specifically explored after taking into account dietary and other risk factors for colorectal adenomas. Results from the two studies were inconsistent with each other but overall offered little support for an association between phenolphthalein-containing laxative use and risk of polyps. The report was published in 1997.