C. elegans models for human transport disorders

描述(由申请人提供)： 这项拟议研究的目标是开发一种或多种线虫基因 肠、肾转运体缺陷模型的建立。我们已经确认了八个 直接与消化和肾脏有关的转运蛋白的线虫同源物 疾病或其他被认为对这些器官的功能很重要的疾病。 在这个项目中，我们建议表征基因的表达模式 线虫蛋白，并确定具有缺陷的动物的特性 功能。根据这一信息，稳定丧失的功能突变将 寻找那些被认为是最有希望的候选基因 转运蛋白疾病模型。

DESCRIPTION (provided by applicant): The goal of the proposed research is to develop one or more C. elegans genetic models for intestine and kidney transporter defects. We have identified eight nematode homologues of transporters directly implicated in digestive and renal disease or otherwise thought to be important in the functions of these organs. In this project, we propose to characterize the expression patterns of the nematode proteins and determine the properties of animals defective in their functions. Based on this information, stable loss of function mutations will be sought for those genes judged to be the most promising candidates for transporter disease models.