EPIDEMIOLOGIC STUDIES OF DIET AND CANCER IN HAWAII

描述(申请人的描述) 这项竞争续期的第号补助金。P01 CA 33619《流行性感冒流行病学研究》 《夏威夷的饮食与癌症》继续探索癌症的病因 以及癌症发病率种族差异的原因。过去的经济周期 格兰特严重依赖病例对照研究，尽管不是唯一的。 探讨饮食与肺、结直肠、子宫内膜、甲状腺、 胃癌、膀胱癌、皮肤癌等癌症。此外，我们还进行了几次 饮食方法论研究。对于这个周期，我们建议利用 最近在夏威夷发起了一个多种族队列，以建立一个 血液和尿液样本的生物库，并利用这一资源来测试 与生物标志物和选定的癌症部位有关的几个假说。 在四年的时间里，将从队列中收集生物样本 日本人、高加索人和夏威夷土著民族的参与者 瓦胡岛，利用当地一家诊所广泛分布的设施 实验室。基于预期的总体回复率为62%，我们 将从18,535名男性和20,452名女性身上获取样本。此外，a 将进行校准子研究，以使我们能够针对测量进行调整 生物标志物有误。生物样品将被储存在多个等量罐中 -150℃(血液)和-80℃(尿液)。结直肠癌、肺、 参与者中的乳腺癌和前列腺癌将通过 夏威夷肿瘤登记处的快速报告。血液和尿液标志物 将检查包括：1)维生素D代谢物、叶酸和同型半胱氨酸， 异硫氰酸酯、胰岛素和葡萄糖、胰岛素样生长因子以及 与结直肠癌相关的选定遗传标记；2)类胡萝卜素， 生育酚、维生素C、总酚、异硫氰酸酯、硒和 异前列腺素与肺癌的关系；3)植物雌激素、类胡萝卜素、 生育酚、胰岛素样生长因子、雌激素和雄激素 与乳腺癌的关系；以及4)硒、植物雌激素、类胡萝卜素、 生育酚、脂肪酸、胰岛素样生长因子、异前列腺素和 雄激素与前列腺癌的关系。所有四个项目都将使用嵌套的 病例对照设计，将由四个核心组件提供支持：1) 管理，2)数据收集，3)生物检疫，4)数据管理 和分析。通过利用夏威夷独特的资源，即 多民族队列研究，这一项目将有助于及时解决某些问题 与癌症的营养病因相关的问题。

DESCRIPTION (Applicant's Description) This competing renewal of grant No. P01 CA 33619 "Epidemiologic Studies of Diet and Cancer in Hawaii" continues to explore etiologic factors for cancer and reasons for ethnic variations in cancer incidence. Past cycles of the grant relied heavily, though not exclusively, on case-control studies to explore the relationship of diet to lung, colorectal, endometrial, thyroid, gastric, bladder, skin and other cancers. In addition, we conducted several dietary methodology studies. For this cycle, we propose to take advantage of a recently initiated multi-ethnic cohort in Hawaii to establish a biorepository of blood and urine specimens, and to use this resource to test several hypotheses related to biological markers and selected cancer sites. Over a period of four years, biological samples will be collected from cohort participants of Japanese, Caucasian and Native Hawaiian ethnicity on the island of Oahu, utilizing the widely dispersed facilities of a local clinical laboratory. Based on an anticipated overall response rate of 62 percent, we will obtain samples from 18,535 males and 20,452 females. In addition, a calibration substudy will be conducted to enable us to adjust for measurement error in the biomarkers. The biospecimens will be stored in multiple aliquotso at -150 C (blood) and -80C (urine). Incident cases of colorectal, lung, breast and prostate cancer among the participants will be identified through rapid reporting by the Hawaii Tumor Registry. Blood and urinary markers that will be examined include: 1) vitamin D metabolites, folate and homocysteine, isothiocyanates, insulin and glucose, insulin-like growth factors, and selected genetic markers in relation to colorectal cancer; 2) carotenoids, tocopherols, vitamin C, total phenol, isothiocyanates, selenium, and isoprostane in relation to lung cancer; 3) phytoestrogens, carotenoids, tocopoherols, insulin-like growth factors, estrogens, and androgens in relation to breast cancer; and 4) selenium, phytoestrogens, carotenoids, tocopoherols, fatty acids, insulin-like growth factors, isoprostane, and androgens in relation to prostate cancer. All four projects will use a nested case-control design and will be supported by four Core Components: 1) Administration, 2) Data Collection, 3) Biospecimens, and 4) Data Management and Analysis. By taking advantage of a unique resource in Hawaii, namely, the Multi-ethnic Cohort Study, this project will help address certain timely issues related to the nutritional etiology of cancer.