Data from The Collaborative Perinatal Project

合作围产期项目(CPP)是一个丰富的数据集，用于调查与孕产妇和儿童健康有关的各种主题。最近的项目也开始利用从孕妇及其新生儿收集的血清作为这项研究的一部分，它与最初研究收集的数据一起提供了一个独特的资源。2001财年调查的领域包括妊娠高血压疾病的研究、双胞胎7岁时出生体重和血压之间的关系、婴儿白内障的风险因素以及随后成人发作精神分裂症的围产期风险因素。在后一项研究中，来自CPP普罗维登斯和波士顿地点的100多名成年后发展为精神分裂症的人被确认，并与200多名没有明显精神病理的队列成员进行匹配。在母体和脐带血清中寻找缺氧、病毒感染和免疫激活的证据。计划于2002年进行的分析包括孕妇在怀孕期间血清转化为SV-40病毒(1963年之前受污染的索尔克脊髓灰质炎疫苗的结果)，作为儿童癌症的风险因素。

The Collaborative Perinatal Project (CPP) is a rich data set for the investigation of a variety of topics related to maternal and child health. Recent projects have also begun to utilize the serum collected from pregnant women and their neonates as part of this study, which, along with data collected as for the original study and subsequently, provides a unique resource. Areas investigated in FY 01 include studies of hypertensive disorders of pregnancy, the association between birth weight and blood pressure at age seven in twins, risk factors for infantile cataract, and perinatal risk factors for subsequent adult-onset schizophrenia. In the latter study, over 100 individuals from the Providence and Boston sites of the CPP who developed schizophrenia as adults were identified and matched to over 200 cohort members who did not have significant psychiatric pathology. Evidence of hypoxia, viral infection, and immune activation was sought in maternal and umbilical cord serum. Planned analysis for 2002 include maternal seroconversion to SV-40 virus during pregnancy (a result of contaminated Salk polio vaccine before 1963) as a risk factor for childhood cancer.