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Recombinant Vaccines Against Retrovirus: Aids

Recombinant Vaccines Against Retrovirus: Aids
抗逆转录病毒重组疫苗：艾滋病
批准号：
6506830
负责人：
BERNARD MOSS
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/6506830
关键词：
AIDS AIDS therapy AIDS vaccines HIV infections biotechnology cellular immunity enzyme linked immunosorbent assay flow cytometry human immunodeficiency virus humoral immunity laboratory mouse nonhuman therapy evaluation nucleic acid sequence polymerase chain reaction recombinant virus simian immunodeficiency virus vaccine development vaccinia virus virus DNA virus antigen virus envelope

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中文摘要
翻译
人类免疫缺陷病毒（HIV）感染是获得性免疫缺陷综合征（AIDS）发展的决定性因素。目前还没有有效的疫苗来预防这种疾病。该项目的目标是确定HIV抗原的特征，确定体液和细胞介导免疫的靶点，并利用这些信息开发候选疫苗。我们已经构建了包含HIV和密切相关的猿免疫缺陷病毒的遗传信息的重组牛痘病毒。这些重组病毒已被用于制备纯化的免疫原、单克隆抗体、细胞毒性T细胞的靶点和候选疫苗
英文摘要
Human immunodeficiency virus (HIV) infection is the determining factor in the development of acquired immunodeficiency syndrome (AIDS). At present there is no effective vaccine against this disease. The objectives of this project are to characterize HIV antigens, determine the targets of humoral and cell mediated immunity, and to use this information to develop candidate vaccines. We have constructed recombinant vaccinia viruses containing genetic information of HIV and the closely related simian immunodeficiency virus. These recombinant viruses have been used to prepare purified immunogens, monoclonal antibodies, targets for cytotoxic T cells and candidate vaccines
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VIRUS HOST INTERACTIONS
REGULATION OF VACCINIA VIRUS GENE EXPRESSION
Development of Vaccinia Virus as an Expression Vector
Recombinant and Attenuated Vaccines
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