EYE DISEASE, DISABILITY AND MORTALITY RISK IN US ADULTS

描述：（申请人的摘要）视力障碍（VI）和眼睛残疾 成人疾病可能导致严重后果，包括社会 孤立，认知障碍，功能状态受损，运动增加 交通事故风险、福尔斯和骨折风险以及死亡率。 不幸的是，成人视力障碍的流行病学仍然很差， 少数群体和低收入群体等亚群体的特点 社会经济阶层（SES）。 国家健康访问调查（NHIS）是美国的一项家庭调查。 国家卫生中心每年对平民进行一次 统计（国家统计中心）。从1986年至1994年，人口、健康、视力和眼病数据 已经收集了超过121,000名美国成年人。最近，NCHS进行了一次 对1986- 1994年参加NHIS的所有个人进行死亡率随访 调查。使用这个具有独特代表性的大型数据库， 研究者将：1）估计自我报告的VI的患病率和程度 按年龄、性别、种族、社会经济地位和 地理区域; 2）比较VI患病率随时间的趋势， 在不同的社会人口亚组中选择的眼病; 3）估计 目前居住在美国的患有VI和选定眼病的成年人数量 4）预测美国人数量的估计变化 5）评估健康和残疾状况; 患有和不患有VI和选定眼病的成人的状态，并确定是否 这些关联在不同的社会人口亚组中有所不同;以及6） 计算和比较成人的总体死亡率和特定原因死亡率 有或没有VI和选定的眼病。 这项研究将解决愿景中概述的三个NEI研究重点 研究，“1999-2003年国家计划”：1）确定流行率（和 发病率）的VI和视力残疾，并确定亚群， VI和残疾的风险增加; 2）确定美国人的数量 与眼病和VI，并衡量对医疗费用和成本的影响， 与这些条件相关的社会;和3）提高我们对 青光眼的性质和病程，合并共病研究， 自然史和遗传学，特别强调西班牙裔，土著 美国人和非洲裔美国人。

DESCRIPTION: (Applicant's Abstract) Visual impairment (VI) and disabling eye diseases in adults can lead to serious consequences, including social isolation, cognitive impairment, impaired functional status, increased motor vehicle accident risk, risk of falls and fractures, and mortality. Unfortunately, the epidemiology of vision disorders in adults remains poorly characterized in subgroups such as minorities and those residing in lower socioeconomic strata (SES). The National Health Interview Survey (NHIS) is a household survey of the US civilian population conducted annually by the National Center for Health Statistics (NCHS). From 1986-94, demographic, health, VI and eye disease data have been collected on over 121,000 US adults. Recently, NCHS conducted a mortality follow-up for all individuals participating in the 1986-94 NHIS surveys. Using this uniquely representative and large database the Investigators will: 1) estimate the prevalence and degree of self-reported VI and selected eye diseases in adults by age, gender, ethnicity, SES, and geographic region; 2) compare trends over time in the prevalence of VI and selected eye diseases in different sociodemographic subgroups; 3) estimate the number of adults currently residing in the US with VI and selected eye diseases by these subgroups; 4) project estimated changes in the number of Americans with these conditions to the year 2020; 5) evaluate the health and disability status of adults with and without VI and selected eye diseases and determine if these associations vary in different sociodemographic subgroups; and 6) calculate and compare the overall and cause specific mortality rates for adults with and without VI and selected eye diseases. This study will address three NEI research priorities outlined in Vision Research, "A National Plan 1999-2003": 1) ascertain the prevalence (and incidence) of VI and visual disability in the US and identify subpopulations at heightened risk for VI and disability; 2) determine the number of Americans with eye disease and VI and measure the impact on medical costs and costs to society associated with these conditions; and 3) improve our understanding of the nature and course of glaucoma, incorporating studies of co-morbidity, natural history, and genetics, with special emphasis on Hispanic, Native American, and African-American populations.