PSYCHOPHYSIOLOGY OF SCHIZOPHRENIA

描述(改编自申请人的摘要)：本报告的总体目标 建议的研究事业奖(K02)旨在为私人投资委员会提供时间：(1) 参与一个跨学科、多地点的研究项目 精神分裂症的心理生理学和(2)获得额外的知识和 技能，以便更好地将认知科学、临床科学和 神经科学。更具体地说，皮肤电活动和预脉冲 惊恐眨眼反射的抑制(PPI)将在四个月内测量 在三个不同地点进行的一系列研究项目，以测试预测 源自精神分裂症的脆弱-应激模型。 第一个项目调查皮肤电活动的变化是否可以 有助于预测精神分裂症的症状性加重/复发 病人。第二个项目检查精神分裂症患者的PPI缺陷 是由于自动过程、受控过程或 两者都有。第三个项目测试PPI损伤是否在两个项目中都表现出来 被动和注意主动的范例也出现在未受影响的兄弟姐妹中 精神分裂症患者。第四个项目探讨了 脑部结构异常与电刺激和PPI有关 精神分裂症患者和分裂型个体的异常。在……里面 除了这四个研究项目外，K02还将允许PI 接受有关技术和原则的正式和非正式培训 临床科学和神经科学。

DESCRIPTION (adapted from applicant's abstract): The overall aims of this proposed Research Career Award (K02) are to provide time for the PI to: (1) engage in an interdisciplinary, multi-site program of research on the psychophysiology of schizophrenia and (2) gain additional knowledge and skills in order to better integrate cognitive science, clinical science and neuroscience. More specifically, electrodermal activity and prepulse inhibition (PPI) of the startle eyeblink reflex will be measured in four sets of research projects at three different sites to test predictions derived from a vulnerability-stress model of schizophrenia. The first project investigates whether changes in electrodermal activity can help in the prediction of symptomatic exacerbation/relapse in schizophrenia patients. The second project examines whether schizophrenia PPI deficits are due to dysfunctions in automatic processes, controlled processes, or both. The third project tests whether PPI impairments demonstrated in both passive and attentionally active paradigms also occur in unaffected siblings of schizophrenia patients. The fourth project explores whether abnormalities in brain structures are related to electrodermal and PPI anomalies in schizophrenia patients and schizotypal individuals. In addition to these four research projects, the K02 will permit the PI to receive formal and informal training in techniques and principles of clinical science and neuroscience.