IMPROVING THE DETECTION LIMIT OF POTENTIOMETRIC SENSORS

本研究为实验和理论研究奠定了基础 电位型检测型离子传感器的研制基础 在微摩尔到皮摩尔范围内的极限。分析离子的流量来自于 膜进入样品，通常在局部扰动样品 感测表面将通过化学手段最小化。相关零电流离子 塑化聚合物膜内的通量将通过 荧光成像技术及其与适当电位漂移的关联 实验。将开发详细的离子通量扩散模型，并 与实验结果相关联。膜内扩散系数 将用新的聚氨酯材料系统地改变相态 基于低检出限传感的固定化离子能组分 申请。这种聚合物还将被用来设计多层膜 相，这将被应用于在 薄膜。基于其的微型、微米尺寸的光学传感器 离子膜组件将进行优化，以实现低检测限 应用及其性能与其电位计进行了关键的比较 对口单位。

This research establishes the experimental and theoretical foundation for the development of potentiometric ion sensors with detection limits in the micromolar to picomolar range. The flux of analyte ions from the membrane into the sample which ordinarily perturbs the sample locally at the sensing surface will be minimized by chemical means. Relevant zero-current ion fluxes within plasticized polymeric membranes will be monitored with fluorescence imaging techniques and correlated to appropriate potential drift experiments. Detailed ion flux diffusion models will be developed and correlated to experimental findings. Diffusion coefficients within the membrane phase will be systematically altered with new polyurethane materials with immobilized ionophoric components in view of low detection limit sensing applications. Such polymers will be also used to devise multi-layered membrane phases, which will be applied to generate robust ion gradients within the membrane. Miniature, micrometer sized optical sensor based on the same ionophoric membrane components will be optimized for low detection limit applications and their performance critically compared to their potentiometric counterparts.