A Laser-Activated Reactor for Biomedical C-14-AMS

描述(由申请人提供)： 本项目的目标是开发出第一个高效、连续 用于将液态样品转换为气相样品的系统 在C-14生物医学加速器质谱仪中的应用。分析 目前，使用AMS的生物样本受到无法 直接接受液体样品的仪器，特别是 无法接受从传统分离系统洗脱出来的样品，如 作为高效液相色谱仪。该系统实现了对样品的液相分析。 通过从溶剂中蒸发分离分析物的过程 通过催化将样品碳燃烧成二氧化碳，以促进 传输到AMS离子源中。该系统的一个独特功能是特定于站点的 连续定向激光在催化剂床上加热样品 高选择性和高选择性样品碳的有效燃烧辐照 受控制的时尚。该系统保留了存储的样本的分辨率 在催化剂床上。该系统将与紧凑型生物医学AMS相耦合 由NSI开发，首次展示了连续检测到 使用AMS从高效液相色谱中标记分子。它也将适合于使用 与其他现有的AMS系统连接。 建议的商业应用： 激光诱导样品转换(LISC)系统将在毒理学、药物开发和相关的14C示踪研究中的生物医学AMS研究中获得广泛的商业应用。LISC-AMS组合系统的成本和大小将与主要医学研究中心的安装兼容。LISC系统还将拥有作为独立产品的商业市场，这将促进任何现有AMS系统的生物医学应用。

DESCRIPTION (provided by applicant): The goal of this project is to develop the first high efficiency, continuous system for conversion of liquid-phase samples to gas-phase samples for application in C-14 biomedical accelerator mass spectrometry. Analysis of biological samples using AMS is currently hampered by the inability of the instruments to accept liquid-phase samples directly, and in particular the inability to accept samples eluted from conventional separation systems such as HPLC. The proposed system accomplishes liquid-phase sample analysis through a process of evaporative separation of analytes from solvent followed by catalyzed combustion of sample carbon to carbon dioxide to facilitate transport into the AMS ion source. A unique feature of the system is site-specific heating of samples on a catalyst bed with continuously directed laser irradiation of effect combustion of sample carbon in a highly selective and controlled fashion. The system preserves the resolution of samples deposited on the catalyst bed. This system will be coupled to a compact biomedical AMS developed by NSI to demonstrate, for the first time, continuous detection of labeled molecules from an HPLC using an AMS. It will also be suitable for use with other existing AMS systems. PROPOSED COMMERCIAL APPLICATION: The laser-induced sample conversion (LISC) system will have widespread commercial applications in biomedical AMS research in toxicology, drug development, and associated 14C tracer studies. The cost and size of a combined LISC-AMS system will be compatible with installation at major medical research centers. The LISC system will also have a commercial market as a stand-alone product that will facilitate biomedical applications of any existing AMS system.