RHESUS CORRAL UPGRADE

描述（由申请人提供）： 该改造项目是ONPRC扩大恒河猴（Macaca mulatta）生产的长期计划的一部分。 这项申请的具体目的是改变和翻新与六个一英亩的corpus相关的30年历史的设施，这些设施拥有SPF印度恒河猴繁殖群。 持续使用Corpus进行恒河猴生产是由以下因素驱动的：1）研究项目的增长和分配给项目的NHP数量需要大幅增加可用的NHP数量; 2）ONPRC是一种国家资源，必须为中心以外的研究人员提供访问权限; 3）长期计划要求将SPF育种计划增加一倍，以建立自给自足的NHP供应; 4）必须扩大动物饲养的储备能力，以进行适当的动物管理;和5）在复杂和环境丰富的社会结构中，饲养动物是一种成本有效的方法。 动物在corpus被用作青少年（艾滋病，传染病，发育神经生物学的研究项目），成年人（免疫学，神经科学和生殖的研究项目）和退休的育种（衰老的研究项目）。 畜栏设施的翻新将使其适合长期使用，包括：1）将第四畜栏和第五畜栏之间的储存区改为第五畜栏的遮蔽饲养区; 2）将现有的第五畜栏饲养区改为安全处理动物的区域; 3）更新基础设施（4）更换所有饲养和饲养区破损的屋顶;（5）更换所有结构上损坏和磨损的金属板; 6）修复和重新密封所有饲养和饲养区的混凝土; 7）在所有饲养和饲养区安装额外的辐射加热器和照明; 8）为冲洗系统安装一个水压增压泵; 9）在所有饲养区增加栖息地; 10）更换所有饲养区日益恶化的动物富集设备。 这项申请将提供资金，用于翻新与六个一英亩的corpus相关的设施。 为了继续使用Corpus以扩大恒河猴生产，并遵守美国农业部（USDA）的政策和动物福利法（AWA）的规定，有必要进行翻新。

DESCRIPTION (provided by applicant): The renovation project is part of a long-range plan to expand rhesus macaque (Macaca mulatta) production at the ONPRC. The specific aim of this application is to alter and renovate the 30-year-old facilities associated with six one-acre corrals that hold SPF Indian rhesus macaque breeding colonies. The continued use of the corrals for rhesus macaque production is driven by the following: 1) the growth in research projects and the numbers of NHPs assigned to projects requires a substantial increase in the number of available NHPs; 2) the ONPRC is a national resource and must provide accessibility to investigators outside of the Center; 3) the long-range plan calls for the doubling of SPF breeding program to create a self-sustaining supply of NHPs; 4) the reserve capacity for animal housing must be expanded for proper animal management; and 5) the corrals are a cost effective method for breeding and raising animals into adulthood in a complex and environmentally rich social structure. Animals in the corrals are used as juveniles (research programs in AIDS, infectious diseases, developmental neurobiology), adults (research programs in immunology, neuroscience and reproduction) and retired breeders (research programs in aging). The renovation of the corral facilities will make them suitable for long-term use and includes the following: 1) convert the storage area between corrals four and five into a sheltered feeding area for corral five; 2) convert the existing corral five feeding area into an area for safe handling of animals; 3) upgrade the infrastructure (electric service, domestic water, sanitary sewer) for all rhesus corral facilities; 4) replace the deteriorated roofs on all feeding and holding areas; 5) replace damaged and worn metal panels on all structures; 6) repair and reseal concrete in all feeding and holding areas; 7) install additional radiant heaters and lights in all feeding and holding areas; 8) install a water pressure booster pump for wash down systems; 9) add perching to all feeding areas; and 10) replace deteriorating animal enrichment equipment in all corrals. This application will provide funds for the renovation of facilities associated with six one-acre corrals. The renovation is necessary for continued use of the corrals to expand rhesus macaque production and to comply with United States Department of Agriculture (USDA) policies and provisions of the Animal Welfare Act (AWA).