Epigenetic determination of neuronal vulnerability and neurodegenerative disease
Epigenetic determination of neuronal vulnerability and neurodegenerative disease
批准号:
nhmrc : GNT1128381
负责人:
A/Pr Massimo Hilliard
金额:
$61.79万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2017
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2017-01-01 至 --
中文摘要
神经元每天都面临着各种形式的压力。神经疾病加剧了这种压力,导致正常情况下允许神经元正常工作的基因受到干扰。结果,神经元死亡,严重的损失会导致痴呆等疾病。我们在神经元中发现了新的分子因子,使它们的基因免受压力的影响,从而保护神经元的功能和健康。拟议的研究将利用这些机制来更好地保护神经元免受疾病的侵害。
英文摘要
Neurons are faced with diverse forms of stress everyday. Neural diseases exacerbate this stress, causing interference to genes that normally allow neurons to function correctly. As a result, neurons die, and severe loss can result in diseases such as dementia. We have discovered new molecular factors in neurons that insulate their genes from stress, thereby protecting neuron function and health. The proposed research will exploit these mechanisms to better protect neurons from disease.
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会议论文
Identification and study of novel conserved molecule with an axonal protective function
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批准号:nhmrc : GNT1145896
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项目类别:Project Grants
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资助金额:$62.5万
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财政年份:2018
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负责人:A/Pr Massimo Hilliard
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依托单位:
Identification and study of novel conserved molecule with an axonal protective function
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批准号:nhmrc : 1145896
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项目类别:Project Grants
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资助金额:$42.26万
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财政年份:2018
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负责人:A/Pr Massimo Hilliard
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依托单位:
Understanding axonal fusion: an alternative mechanism to repair injured axons.
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批准号:nhmrc : 1129367
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项目类别:Project Grants
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资助金额:$44.25万
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财政年份:2017
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负责人:A/Pr Massimo Hilliard
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依托单位:
Understanding axonal fusion: an alternative mechanism to repair injured axons.
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批准号:nhmrc : GNT1129367
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项目类别:Project Grants
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资助金额:$64.84万
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财政年份:2017
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负责人:A/Pr Massimo Hilliard
-
依托单位:
Epigenetic determination of neuronal vulnerability and neurodegenerative disease
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批准号:nhmrc : 1128381
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项目类别:Project Grants
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资助金额:$42.17万
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财政年份:2017
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负责人:A/Pr Massimo Hilliard
-
依托单位:
Axonal regeneration and degeneration: cellular and molecular mechanisms
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批准号:nhmrc : GNT1111042
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项目类别:Research Fellowships
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资助金额:$62.27万
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财政年份:2016
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负责人:A/Pr Massimo Hilliard
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依托单位:
The role of membrane phospholipids in regenerative axonal fusion
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批准号:nhmrc : GNT1101974
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项目类别:Project Grants
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资助金额:$57.2万
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财政年份:2016
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负责人:A/Pr Massimo Hilliard
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依托单位:
Axonal regeneration and degeneration: cellular and molecular mechanisms
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批准号:nhmrc : 1111042
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项目类别:Research Fellowships
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资助金额:$42.93万
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财政年份:2016
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负责人:A/Pr Massimo Hilliard
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依托单位:
The role of membrane phospholipids in regenerative axonal fusion
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批准号:nhmrc : 1101974
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项目类别:Project Grants
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资助金额:$39.22万
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财政年份:2016
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负责人:A/Pr Massimo Hilliard
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依托单位:
Axonal fusion to promote nerve repair: molecules and mechanisms.
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批准号:nhmrc : 1068871
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项目类别:Project Grants
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资助金额:$30.42万
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财政年份:2014
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负责人:A/Pr Massimo Hilliard
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依托单位:
Understanding the role of TDP-43 in motor neuron disease.
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批准号:nhmrc : 1067461
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项目类别:Project Grants
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资助金额:$43.61万
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财政年份:2014
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负责人:A/Pr Massimo Hilliard
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依托单位:
Membrane fusion in axonal regeneration: molecules and mechanisms
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批准号:nhmrc : 631634
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项目类别:NHMRC Project Grants
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资助金额:$30.78万
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财政年份:2010
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负责人:A/Pr Massimo Hilliard
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依托单位:
Discovering molecules and mechanisms regulating dendrite formation
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批准号:nhmrc : 631605
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项目类别:NHMRC Project Grants
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资助金额:$34.54万
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财政年份:2010
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负责人:A/Pr Massimo Hilliard
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依托单位:
Axonal degeneration in C. elegans neurons
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批准号:nhmrc : 569500
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项目类别:NHMRC Project Grants
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资助金额:$34.09万
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财政年份:2009
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负责人:A/Pr Massimo Hilliard
-
依托单位:
国内基金
海外基金
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