Epithelial cell signalling and host responses to virulent Helicobacter pylori strains.

幽门螺杆菌（Helicobacter pylori）是引起胃肠道疾病的主要病原菌之一。然而，仍然困扰该领域研究人员的一个问题是，为什么一些感染者会发展出非常严重的疾病（溃疡或癌症），而其他人只会发展出炎症。本课题将对H.幽门螺杆菌与胃壁细胞的相互作用，以及这些相互作用如何导致更严重的疾病的发展。

The stomach bacterium Helicobacter pylori causes various types of gastrointestinal disease. One of the questions that still perplexes researchers in the field, however, is why some infected individuals develop very severe forms of disease (ulcers or cancer) whilst others develop only inflammation. This project will investigate H. pylori interactions with cells that line the stomach wall and how these interactions may contribute to the development of more severe disease.