MRFASS--MINORITIES, RISK FACTOR AND STROKE STUDY

描述：(改编自申请人摘要)。这样做的目的是 这两个项目都是为了确定三个城市中风复发的风险 种族群体、非裔美国人、拉丁裔和非拉丁裔白人以及 确定这些人群中复发的危险因素。 非洲裔美国人和拉美裔美国人似乎面临更大的风险，不仅是因为 最初的中风，也是中风复发的原因。随着人口老龄化和 中风死亡率下降，中风复发风险的人数 升起。至少25%的中风住院患者是反复发作的 中风。因此，复发性中风是一个巨大且不断增长的公共卫生问题 担忧。自从中风患者就医以来，他们是一名 容易识别的需要预防性卫生措施的人群。 确定他们复发中风风险的主要组成部分将提供 这些措施的重点。 为了确定研究人群中的复发风险因素，一组 将在六年内招募约990名患者，并 长达四年的跟踪调查。再发中风的可能危险因素 将在索引笔划时识别。重大风险管控 因素包括高血压、高血糖、吸烟、饮酒和 每年将由面对面监督处方治疗的遵守情况 后续行动。终末器官受累的测量方法(即颈动脉壁 厚度、左心室肥厚和顺应性)将在 中风后两年。无中风存活率将被估计为 每个民族和复发的独立决定因素将是 用多元统计技术进行识别。

DESCRIPTION: (Adapted from Applicant's Abstract). The purposes of this project are both to determine the risk of recurrent stroke in three urban ethnic groups, African-Americans, Latinos, and white non-Latinos and to determine the risk factors for recurrence in these groups. African-Americans and Latinos appear to be at greater risk, not only for initial stroke, but also for stroke recurrence. As the population ages and stroke mortality declines, the number of people at risk for recurrent stroke rises. At least 25% of hospital admissions for stroke are recurrent strokes. Recurrent stroke is therefore a large and growing public health concern. Since patients with stroke come to medical attention they are an easily identified group of people in need of preventive health measures. Identifying the major components of their recurrent stroke risk will provide a focus for these measures. To identify recurrent risk factors in the groups under study, a cohort of approximately 990 patients will be enrolled over a six year period and followed for up to four years. Putative risk factors for recurrent stroke will be identified at the time of index stroke. Control of major risk factors including hypertension, hyperglycemia, smoking, alcohol use and compliance with prescribed treatment will be monitored annually by in-person follow-up. Measures of end-organ involvement (viz., carotid artery wall thickness, left ventricular hypertrophy and compliance) will be obtained at two years post-stroke. Stroke-free survival rates will be estimated for each ethnic group and the independent determinants of recurrence will be identified with multivariate statistical techniques.