New Non-invasive Imaging Methods For Biomedical Applicat

在过去的一年中，我们利用我们称为DENSE的小组开发的MRI相移技术来绘制一组正常志愿者心脏的三维收缩运动作为试点研究，并获得了对心脏生物力学的新见解。我们还继续在正常呼吸条件下进行导航仪引导的心脏运动成像。这种方法允许心脏成像，而对患者没有屏气的特殊要求，并延长了收集更详细图像的可用时间。 我们开始了一项新的计划，在犬模型中精确绘制心脏灌注。我们使用流动血液的固有特性来实现这一目标，此外，我们开始研究基于造影剂的方法来准确测量动脉血液的输送和红细胞的运动。 我们获得了初步的结果，在一个新的方式来测量组织的电特性，非侵入性的高场磁共振成像。本研究所获得的知识将有助于人体射频场行为的建模和高场MRI射频线圈的优化。

In the last year we utilized the MRI phase-shift technique developed by our group called DENSE to map the three-dimensional contractile motion of the human heart in a group of normal volunteers as a pilot study, and obtained new insight into the biomechanics of the heart. We also continued the work of navigator guided motion imaging of the heart under normal breathing conditions. This approach allows imaging of the heart with no particular demand on the patients for breath holding, and extends the available time for collecting more detailed images. We started a new initiative in accurately mapping the perfusion of the heart in canine models. We used an intrinsic property of flowing blood to accomplish this goal, and additionally we begin to investigate contrast based methods to accurately measure the delivery of arterial blood and the movement of eurythrocytes. We obtained preliminary results in a new way to measure tissue electrical properties non-invasively in high field magnetic resonance imaging. The knowledge acquired with this study will help the modeling of RF field behavior in the human body and the optimization of RF coils for high field MRI.