Latent Reactive Groups for Biomaterials

描述（由申请人提供）： 已开发出具有在人体内发挥功能的医疗器械所需的整体物理性质的材料。目前主要重点放在植入式医疗器械的表面化学上，以提供与活组织的生物相容性和润滑性，从而确保植入的安全性和易用性。基于自由基的表面改性已经发展到商业可用性快速增长的地步（基于三重态羰基光化学的PhotoLink涂层）。这些表面改性能量源对于“不透明”医疗器械（如中心静脉通路和血液透析导管以及中空纤维膜）的内表面无效。该项目旨在进一步开发可由热能激活的潜在反应性自由基发生器，这种发生器很容易穿透这些“不透明”的医疗设备。第II阶段的目标包括优化第I阶段的新试剂，用于将亲水性血液相容性聚合物粘合到生物材料（例如聚丙烯、聚氨酯、硅橡胶）上。这些新的异型双功能试剂的用途将被证明用于1）掺入可溶性聚合物衍生物中，然后热化学偶联到表面，和2）活化生物材料表面，然后偶联到可溶性聚合物衍生物。这种激活自由基发生器的创新方法有望促进“惰性”医疗器械的表面改性，这些医疗器械无法用外部光源的长波长光子激活。

DESCRIPTION (provided by applicant): Materials have been developed with bulk physical properties needed for medical devices functioning in the human body. Major emphasis is now being placed on surface chemistry for implantable medical devices to provide biocompatibility with the living tissue and lubricity for safety and ease of implantation. Radical-based surface modification has been developed to the point of rapid growth in commercial availability (PhotoLink coatings based on triplet carbonyl photochemistry). These surface modification energy sources are not effective for the inner surfaces of "opaque" medical devices such as central venous access and hemodialysis catheters and hollow fiber membranes. This project is designed to further develop latent-reactive radical generators activatible with thermal energy, which readily penetrates these "opaque" medical devices. The Phase II aims include optimization of the new reagents of Phase I, for bonding hydrophilic blood compatible polymers to biomaterials (e.g. polypropylene, polyurethane, silicone rubber). The use of these new heterobifunctional reagents will be demonstrated for 1) incorporating into the soluble polymer derivative followed by thermo chemical coupling to the surface and 2) activating the biomaterial surface, followed by coupling to soluble polymer derivatives. This innovative approach to activation of radical generators is expected to facilitate the surface modification of "inert" medical devices, which cannot be activated with long-wavelength photons for external light sources.