MOUSE PATHOBIOLOGY: MODELS OF HUMAN DISEASE

描述(申请者提供)：OSU小鼠病理生物学培训 计划是一个为期四年的计划，旨在培养兽医科学家 能够使用鼠标进行独立和协作的研究 人类疾病的模型。实习生将从有进取心和才华的人中挑选出来 D.V.M.或D.V.M.，致力于研究事业的博士生。 学员将完成为期一年的兽医专业教育 病理学、临床病理学、微生物学或实验动物医学 这将包括三个月的轮换，通过实验室动物 程序。第一年将由兽医部提供资金 生物科学。那么T32培训计划将需要三年时间 哪些学员将在一次培训中完成独立研究项目 教员的实验室。没有博士学位的实习生将攻读 比较病理学与实验病理学在兽医系的应用 生物科学。研究项目将重点放在使用鼠标模型来 研究人类重大疾病的病理生理学。培训 教师(24名成员)专注于比较癌症方面的卓越研究 医学、传染病、免疫学和遗传学的发展 改变了人类疾病的小鼠模型。所有培训教员都使用实验性 在他们的工作中建立了人类疾病的老鼠模型。24名培训教职员工 代表了兽医生物科学的不同领域的研究人员， 内科、医学生化和生理学、癌症遗传学、小鼠 遗传学、外科、分子生物学和口腔生物学已经发展出一种 俄亥俄州立大学健康中心内的协作互动网络 科学中心(由七所学院组成)。培训人员 代表兽医、医学、生物科学学院， 还有牙科。俄亥俄州立大学综合癌症中心(包括其核心 服务)、詹姆斯癌症医院和索洛夫研究所，以及转基因 神经生物技术中心和儿童医院的核心是 俄亥俄州立大学的组织将促进研究计划和 培训教员互动。选定的正式课程将被选为 根据他们的需求和目标培训学员。该计划的完成将 使受训人员能够发展在体内进行设计和实施所需的技能 实验，并在学术或工业领域担任顾问 促进使用人类老鼠模型的研究项目的机构 疾病。

DESCRIPTION (Provided by applicant): The OSU Mouse Pathobiology training program is a four-year program designed to produce veterinary scientists capable of conducting independent and collaborative research using mouse models of human disease. Trainees will be selected from motivated and talented D.V.M. or D.V.M., Ph.D. candidates who are committed to careers in research. Trainees will complete one year of specialty education in veterinary pathology, clinical pathology, microbiology, or laboratory animal medicine that will include a three month rotation through the Laboratory Animal Program. The first year will be funded by the Department of Veterinary Biosciences. Then the T32 training program will require three years during which trainees will complete independent research projects within a training faculty's laboratory. Trainees without a Ph.D. degree will pursue a Ph.D. in Comparative and Experimental Pathobiology in the Department of Veterinary Biosciences. The research projects will focus on using mouse models to investigate the pathophysiology of significant human diseases. The training faculty (24 members) have focused research excellence in comparative cancer medicine, infectious diseases, immunology, and development of genetically altered mouse models of human disease. All training faculty use experimental mouse models of human disease in their work. The 24 training faculty represent a diverse spectrum of investigators in veterinary biosciences, internal medicine, medical biochemistry and physiology, cancer genetics, mouse genetics, surgery, molecular biology, and oral biology that have developed a network of collaborative interactions within The Ohio State University Health Sciences Center (consisting of seven colleges). The training faculty represent the Colleges of Veterinary Medicine, Medicine, Biologic Sciences, and Dentistry. The OSU Comprehensive Cancer Center (including its core services), James Cancer Hospital and Solove Research Institute, and transgenic cores of the Neurobiotechnology Center and Children's Hospital are organizations at the OSU that will facilitate the research programs and training faculty interaction. Selected formal courses will be chosen for trainees based on their needs and goals. Completion of the program will enable trainees to develop the skills necessary to design and conduct in vivo experiments and serve as resource persons in academic or industrial institutions to facilitate research projects using mouse models of human disease.