HUMAN TISSUE ACQUISITION & PATHOLOGY SHARED RESOURCES

VICC人体组织采集和病理学共享资源（HTAP）的目的是为从事转化和基础科学研究工作的癌症中心研究人员提供支持。它为研究人员提供了各种各样的人体标本和组织。HTAP的目标是收集、处理、储存和分发人体残余组织（正常和肿瘤）从常规手术切除和尸检中获得，供VICC的同行评审资助研究者在基础、临床和转化研究中使用;提供最高质量的表征良好的新鲜、冷冻和固定组织，适用于广泛的分子、生物化学和组织分析;协助特定癌症相关临床试验和其他项目的活检材料的收集和储存;在可行的情况下，向其他同行评审资助的范德比尔特大学研究人员（非VICC成员）和尚未获得资助的新成立研究人员提供人体组织;并进行质量控制以确保相关组织被提供给研究者，并且组织适合于计划的研究（例如，不坏死的或不受未知疾病过程的影响。）HTAP提供的新服务包括激光捕获显微镜、组织阵列块构建以及布利斯自动化软件/成像系统。此外，组织收集工作已经广泛地 提供完善和新的保存方法。Kay华盛顿博士是人体组织采集和病理学共享资源的主任，并与VICC研究人员一起参与了许多合作项目。在玛丽埃杰顿博士的指导下，她得到了一位在提供这些服务方面拥有数十年经验的工作人员的协助，并与生物信息学共享资源合作，开发了易于定制的标本跟踪工具， 将基因组、蛋白质组和生物学数据与组织标本联系起来。

The purpose of the VICC Human Tissue Acquisition and Pathology Shared Resource (HTAP) is to provide support for Cancer Center investigators engaged in translational and basic science research efforts. It provides researchers with access to a wide variety of human specimens and tissues. The objectives of HTAP are to collect, process, bank, and distribute remnant human tissues (both normal and neoplastic) from routine surgical resections and autopsies for use by peer-reviewed funded investigators of the VICC in basic, clinical, and translational research studies; provide the highest quality of well-characterized fresh, frozen, and fixed tissues suitable for a wide range of molecular, biochemical, and tissue analyses; assist with collection and banking of biopsy material for specific cancer-related clinical trials and other projects; provide, as feasible, human tissues to other peer-reviewed funded Vanderbilt University investigators who are not members of the VICC, and to newly-established investigators who have yet to receive funding; and to perform quality control to ensure that the relevant tissue is supplied to the researcher, and that tissues are suitable for the planned research (e.g., not necrotic or involved by unsuspected disease processes.) New services offered by HTAP include laser capture microscopy, tissue array block construction, and access to the BLISS automated software/imaging system. In addition, tissue collection efforts have been extensively refined and new preservation methods offered. Dr. Kay Washington is the Director of the Human Tissue Acquisition and Pathology Shared Resource and is engaged in a number of collaborative projects with VICC investigators. She is assisted by a staff with decades of experience in offering these services, and partners with the Bioinformatics Shared Resource, under the direction of Dr. Mary Edgerton, to develop easily-customized tools for specimen tracking and linkage of genomic, proteomic and biologic data to tissue specimens.