FREQUENCY INTEGRATION IN THE AUDITORY CORTEX

描述：(改编自申请者摘要)：这项工作的目标是 阐明听觉皮质神经活动与声音的关系 感知力。申请人将决定1)人类的能力和 非人灵长类感知和整合光谱和时间特征 声音，以及2)听皮层单个神经元反应的关系 心理生理方面的表现。对于目标1，人类和非人类受试者将是 经过训练以辨别沿时间或频谱维度变化的声音， 对于目标2，神经元将被记录在非人灵长类听觉皮质中 在行为歧视期间。将使用信号检测方法来 确定单个神经元的辨别能力，以及它们的 射击与声音或声音的物理属性更密切相关 更高级别的决定，以响应声音。数据将提供 了解大脑皮层破坏影响的信息，以及 对时间声学处理有基本了解。结果是 治疗中风和阅读障碍的潜在用途。

DESCRIPTION: (Adapted from applicant's abstract): The goal of this work is to elucidate the relationship between neural activity in auditory cortex and sound perception. The applicant will determine 1) the abilities of humans and nonhuman primates to perceive and integrate spectral and temporal features of sounds, and 2) the relationship of single neuron responses in auditory cortex to psychophysical performance. For Aim 1, human and nonhuman subjects will be trained to discriminate sounds that vary along temporal or spectral dimensions, and for Aim 2, neurons will be recorded in nonhuman primate auditory cortex during behavioral discriminations. Signal detection methods will be used to determine the discriminative capabilities of single neurons, and whether their firing is more closely associated with the physical attributes of sound or the higher level decision to respond to the sound. The data will provide information for understanding the effects of cortical disruptions, as well as basic understanding of temporal acoustic processing. The results are of potential use for treating stroke and dyslexia.