Functional Organization of Audition in Schizophrenia

描述（由申请人提供）：人们注意到精神分裂症患者基本听觉感知的改变已经有一段时间了，但对于听觉行为功能的改变与解剖学和生理学的潜在变化之间的关系知之甚少。听力表现差与听力障碍的显著临床症状（如幻听）之间的关系（如果有的话）也知之甚少。我们提议额外拨款5年，继续研究精神分裂症患者听觉皮层基本组织原则的变化特征，以及它们与听觉心理物理学、临床症状学和工作记忆的关系。脑磁图（MEG）、磁共振成像（MRI）和心理声学方法将在80名精神分裂症患者和匹配的对照组中研究这些关系。我们假设听觉生理学的改变，如地形映射紊乱（即，tonotopy）和较差的频率调谐是精神分裂症听觉感知过程基本变化的基础。工作记忆和注意力对精神分裂症患者知觉和生理变化的影响也将被研究。

DESCRIPTION (provided by applicant): Alterations in basic auditory perception in persons with schizophrenia have been noted for some time, but very little is known regarding how the changes in auditory behavioral function relate to underlying changes in anatomy and physiology. The relationship between poor auditory performance and the salient clinical symptoms of the disorder such as auditory hallucinations, if any, is also poorly understood. We are proposing an additional 5 years of funding to continue our efforts to characterize changes in the basic organizational principles of the auditory cortex in schizophrenia and their relationship to auditory psychophysics, clinical symptomatology and working memory. Magnetoencephalography (MEG), magnetic resonance imaging (MRI) and psychoacoustic methods will be employed to study these relationships in 80 people with schizophrenia and matched controls. We hypothesize that alterations in auditory physiology such as disturbed topographic mapping (i.e., tonotopy) and poorer frequency tuning underlie fundamental changes in auditory perceptual processes in schizophrenia. The impact of working memory and attention on perceptual and physiological changes in schizophrenia will also be examined.