High Content Screening for Epithelial Biology

描述（由申请人提供）：BioTechCrystalCorporation（BioTechCrystalTM）提出开发一种用于上皮细胞生理学的高含量细胞筛选系统。该系统将能够在96孔板中同时测量多个细胞荧光团可报告分子种类的动力学响应。将在毫秒时间范围内测量动力学响应，这与许多细胞内动力学过程的时间性质一致。该技术将为高内容筛选和高通量药物筛选提供一种新型的、基于多探针细胞的平台。这种使能技术将为阐明基于细胞的信号转导机制提供主要工具，用于制药工业的药物发现和验证。

DESCRIPTION (provided by applicant): BioTechPlex Corporation (BioTechPlex TM) proposes to develop a high content cellular screening system for epithelial cellular physiology. This system will enable the kinetic responses of multiple cellular fluorophore reportable molecular species to be simultaneously measured in a 96 well plate. The kinetic responses will be measured in a millisecond time frame, consistent with the temporal nature of many intracellular kinetic processes. This technology will provide a novel, multi-probe cellular-based platform for high content screening and high-throughput drug screening. This enabling technology will provide a major tool for the elucidation of cell based signal transduction mechanisms for drug discovery and validation by the pharmaceutical industry.